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极谱法测定药物制剂中的某些头孢菌素。

Polarographic determination of certain cephalosporins in pharmaceutical preparations.

作者信息

Guru Prasad A R, Rao V S

机构信息

Department of Chemistry, ICFAI Foundation for Higher Education, Hyderabad, A.P., India.

出版信息

Res Pharm Sci. 2010 Jan;5(1):57-63.

PMID:21589769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3093099/
Abstract

Polarographic methods have been developed for the determination of two cephalosporins namely cefotaxime (CTX) and ceftriaxone (CTR) in pharmaceutical formulations. Well defined peaks at potentials -1.432 V vs. SCE for CTX and -1.627 V vs. SCE for CTR were obtained in the presence of tungsten (VI). The method has been successfully applied for the determination of above mentioned cephalosporins in commercial dosage forms. The salient features of this investigation are presented in this communication.

摘要

已开发出极谱法用于测定药物制剂中的两种头孢菌素，即头孢噻肟（CTX）和头孢曲松（CTR）。在存在钨（VI）的情况下，获得了CTX在相对于饱和甘汞电极（SCE）电位为-1.432 V时以及CTR在相对于SCE电位为-1.627 V时明确的峰。该方法已成功应用于商业剂型中上述头孢菌素的测定。本通讯介绍了该研究的显著特点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/144da24eff86/JRPS-5-57-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/5f1c3dac0c5e/JRPS-5-57-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/0882e25eadd3/JRPS-5-57-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/9cc675b25039/JRPS-5-57-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/879b6743416c/JRPS-5-57-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/89ad8bddcfab/JRPS-5-57-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/c663263c7fa4/JRPS-5-57-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/144da24eff86/JRPS-5-57-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/bde4f69de2e4/JRPS-5-57-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/5f1c3dac0c5e/JRPS-5-57-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/0882e25eadd3/JRPS-5-57-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/9cc675b25039/JRPS-5-57-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/879b6743416c/JRPS-5-57-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/89ad8bddcfab/JRPS-5-57-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/c663263c7fa4/JRPS-5-57-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ec/3093099/144da24eff86/JRPS-5-57-g010.jpg

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Bioelectrochemistry. 2005 Feb;65(2):95-104. doi: 10.1016/j.bioelechem.2004.09.002.
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