Tang Li, Kubota Masaru, Nagai Ayako, Mamemoto Kimiyo, Tokuda Masakuni
Department of Human Life and Environment, Nara Women's University, Nara, Japan;
Pediatr Rep. 2010 Jun 18;2(1):e12. doi: 10.4081/pr.2010.e12.
The prevalence of hyperuricemia in obese children and adolescents and its association with metabolic syndrome are largely unknown. The objective of our study was to characterize hyperuricemia in relation to metabolic syndrome in Japanese children and adolescents with obesity. Between 2005 and 2008, we performed a cross-sectional study of 1,027 obese children and adolescents aged 6-14 years. Based on the reference value of serum uric acid we had established previously, hyperuricemia was defined as one standard deviation over the mean value at each age. The diagnosis of metabolic syndrome was made based on the Japanese criteria for children. A total of 213 children and adolescents (20.7%) was found to have hyperuricemia. The prevalence of hyperuricemia was significantly higher in the male gender and older age group. Sixty-five out of 213 subjects with hyperuricemia (30.5%) had metabolic syndrome, whereas 111 out of 814 subjects without hyperuricemia (13.6%) had metabolic syndrome. The most common abnormal component of metabolic syndrome was triglyceride, followed by diastolic blood pressure, systolic blood pressure, fasting blood glucose, and HDL-cholesterol. Such a tendency was almost identical between the two groups. We concluded that considering the association between hyperuricemia and metabolic syndrome in obese Japanese children and adolescents, the role of hyperuricemia in metabolic syndrome should receive more attention, beginning in early childhood.
肥胖儿童和青少年高尿酸血症的患病率及其与代谢综合征的关联在很大程度上尚不清楚。我们研究的目的是描述日本肥胖儿童和青少年中高尿酸血症与代谢综合征的关系。在2005年至2008年期间，我们对1027名6 - 14岁的肥胖儿童和青少年进行了一项横断面研究。根据我们之前确定的血清尿酸参考值，高尿酸血症被定义为各年龄组均值加一个标准差以上。代谢综合征的诊断基于日本儿童标准。共有213名儿童和青少年（20.7%）被发现患有高尿酸血症。高尿酸血症的患病率在男性和年龄较大的组中显著更高。213名高尿酸血症受试者中有65名（30.5%）患有代谢综合征，而814名非高尿酸血症受试者中有111名（13.6%）患有代谢综合征。代谢综合征最常见的异常成分是甘油三酯，其次是舒张压、收缩压、空腹血糖和高密度脂蛋白胆固醇。两组之间这种趋势几乎相同。我们得出结论，考虑到日本肥胖儿童和青少年中高尿酸血症与代谢综合征的关联，高尿酸血症在代谢综合征中的作用应从幼儿期开始就受到更多关注。
