Tang Benyu, Li Yinya, Lin Juan, Zhu Yuxing, Chen Danchun, Mou Yikun, Zhu Shunye
Children's Medical Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510630, People's Republic of China.
Diabetes Metab Syndr Obes. 2025 Aug 9;18:2797-2806. doi: 10.2147/DMSO.S527026. eCollection 2025.
Overweight and obesity in children and adolescents have emerged as significant public health issues in China. This study aims to analyze the characteristics of serum uric acid (SUA) metabolism in overweight and obese children and adolescents in South China, exploring its associations with metabolic parameters.
A single-center retrospective study was conducted, involving children and adolescents aged 3 to 18 years diagnosed with overweight and obesity. Spearman correlation coefficients were calculated to evaluate relationships between SUA and other metabolic parameters. Multivariate linear regression analyses were conducted to adjust for confounders. Comparisons were made between participants with hyperuricemia and those with normal SUA levels, and logistic regression analyses were conducted to adjust for confounders. Hierarchical clustering was performed to explore the relationships among the parameters. A dendrogram was generated to visualize the cluster structure.
Among 172 participants (96 males, 76 females), the mean age was 10.88±2.70 years. The prevalence of hyperuricemia was 36.30%, with 38.46% in males and 33.82% in females. Every 1 kg/m² increase in body mass index was associated with a 7.156 µmol/L increase in SUA and an 8.9% increase in hyperuricemia risk. Significant correlations were observed between SUA levels and insulin resistance (HOMA-IR), fasting insulin, and high-density lipoprotein cholesterol. Hierarchical clustering analysis revealed two distinct clusters. One cluster includes SUA along with insulin resistance and lipid metabolism parameters, while the other comprises obesity metrics, urinary microalbumin, and blood glucose.
The findings show a high prevalence of hyperuricemia in overweight and obese children and adolescents, linked to insulin resistance and dyslipidemia. These results highlight the need for early screening and targeted interventions to improve metabolic health outcomes in this vulnerable population.
儿童和青少年超重及肥胖已成为中国重要的公共卫生问题。本研究旨在分析中国南方超重和肥胖儿童及青少年血清尿酸（SUA）代谢特征，探讨其与代谢参数的关联。
进行了一项单中心回顾性研究，纳入3至18岁诊断为超重和肥胖的儿童及青少年。计算Spearman相关系数以评估SUA与其他代谢参数之间的关系。进行多变量线性回归分析以调整混杂因素。比较高尿酸血症参与者和SUA水平正常的参与者，并进行逻辑回归分析以调整混杂因素。进行层次聚类以探索参数之间的关系。生成树状图以可视化聚类结构。
172名参与者（96名男性，76名女性）中，平均年龄为10.88±2.70岁。高尿酸血症患病率为36.30%，男性为38.46%，女性为33.82%。体重指数每增加1kg/m²，SUA升高7.156µmol/L，高尿酸血症风险增加8.9%。SUA水平与胰岛素抵抗（HOMA-IR）、空腹胰岛素和高密度脂蛋白胆固醇之间存在显著相关性。层次聚类分析揭示了两个不同的聚类。一个聚类包括SUA以及胰岛素抵抗和脂质代谢参数，而另一个聚类包括肥胖指标、尿微量白蛋白和血糖。
研究结果表明超重和肥胖儿童及青少年中高尿酸血症患病率较高，与胰岛素抵抗和血脂异常有关。这些结果凸显了对这一脆弱人群进行早期筛查和针对性干预以改善代谢健康结局的必要性。
