Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Chem Commun (Camb). 2011 Jun 28;47(24):6966-8. doi: 10.1039/c1cc12067k. Epub 2011 May 17.
Up to now, the synthesis of quinazolinones has required lengthy synthetic procedures. Here, we describe an innovative one-pot multicomponent reaction leading to highly substituted quinazolinones. We believe that this novel transformation may open the door for the generation of new and pharmacologically active quinazolinones, but, most important of all, the resurrection of the imide-Ugi scaffold paves the way for the synthesis of novel molecular architectures.
到目前为止，喹唑啉酮的合成需要冗长的合成步骤。在这里，我们描述了一种创新的一锅多组分反应，可得到高度取代的喹唑啉酮。我们相信这种新颖的转化可能为新型具有药理活性的喹唑啉酮的生成开辟道路，但最重要的是，酰亚胺-Ugi 支架的复活为新型分子结构的合成铺平了道路。
