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朝着合成含有糖氨基酸的抗菌非细胞毒性 CAP 缀合物与金纳米粒子以及细胞破坏的机制研究前进。

Towards the synthesis of sugar amino acid containing antimicrobial noncytotoxic CAP conjugates with gold nanoparticles and a mechanistic study of cell disruption.

机构信息

CSIR-Central Drug Research Institute, Lucknow 226001, India.

出版信息

Org Biomol Chem. 2011 Jul 7;9(13):4806-10. doi: 10.1039/c1ob05338h. Epub 2011 May 17.

DOI:10.1039/c1ob05338h
PMID:21590000
Abstract

Cationic antimicrobial peptides are potent inhibitors of growth of a broad spectrum of micro-organisms but often have large cytotoxic effects. We prepared some novel sugar amino acid containing cyclic cationic peptides and their Au nanoparticle attached counterparts and studied their antimicrobial activities and cytotoxic behaviour, including an investigation of the mechanism of the cytotoxicity.

摘要

阳离子抗菌肽是广谱微生物生长的有效抑制剂，但往往具有较大的细胞毒性。我们制备了一些新型的糖氨基酸含环阳离子肽及其 Au 纳米粒子附着的对应物，并研究了它们的抗菌活性和细胞毒性行为，包括对细胞毒性机制的研究。

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