el-Mofty M M, Osman S I, Sakr S A, Toulan B A
Zoology Department, Faculty of Science, University of Alexandria, Egypt.
Oncology. 1988;45(1):65-7. doi: 10.1159/000226533.
Feeding the Egyptian toad Bufo regularis for 14 weeks with flour infested for 1 year with Tribolium castaneum, at a dose level of 200 mg/50 g body weight, induced neoplasms in 22 out of 100 toads. These neoplasms comprise 22 primary hepatocellular carcinomas and 6 tumours in the kidney due to metastases from the primary hepatocellular carcinoma. It is speculated that the carcinogenicity of the flour used in this work is due to quinone derivatives secreted by the defensive glands of T. castaneum.
用被赤拟谷盗侵染1年的面粉以200毫克/50克体重的剂量水平喂养埃及蟾蜍（Bufo regularis）14周，在100只蟾蜍中有22只诱发了肿瘤。这些肿瘤包括22例原发性肝细胞癌以及因原发性肝细胞癌转移而在肾脏出现的6个肿瘤。据推测，本研究中所用面粉的致癌性是由于赤拟谷盗防御腺分泌的醌衍生物所致。
