• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

螺环脒类化合物:从分子识别到双功能有机催化的桥梁。

Squaramides: bridging from molecular recognition to bifunctional organocatalysis.

机构信息

Departamento de Química Orgánica (modulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

出版信息

Chemistry. 2011 Jun 14;17(25):6890-9. doi: 10.1002/chem.201003694. Epub 2011 May 17.

DOI:10.1002/chem.201003694
PMID:21590822
Abstract

In this minireview, squaramides are presented from their roots as artificial anion receptors in molecular recognition studies to their recent advances as powerful bifunctional hydrogen-bonding catalysts in asymmetric organocatalysis. The main features of the squaramido functionality and the direct comparison with the analogous ureas and thioureas are also discussed.

摘要

在这篇综述中,我们将从作为分子识别研究中人工阴离子受体的酰胺基唑烷酮的起源开始介绍,一直讨论到其作为在不对称有机催化中具有强大双功能氢键催化作用的最新进展。我们还将讨论酰胺基唑烷酮功能的主要特点,并与类似的脲和硫脲进行直接比较。

相似文献

1
Squaramides: bridging from molecular recognition to bifunctional organocatalysis.螺环脒类化合物:从分子识别到双功能有机催化的桥梁。
Chemistry. 2011 Jun 14;17(25):6890-9. doi: 10.1002/chem.201003694. Epub 2011 May 17.
2
(Thio)urea organocatalysis--what can be learnt from anion recognition?(硫)脲有机催化——从阴离子识别中能学到什么?
Chem Soc Rev. 2009 Apr;38(4):1187-98. doi: 10.1039/b801793j. Epub 2009 Feb 18.
3
Non-racemic atropisomeric (thio)ureas as neutral enantioselective anion receptors for amino-acid derivatives: origin of smaller Kass with thiourea than urea derivatives.非外消旋阻转异构(硫)脲作为氨基酸衍生物的中性对映选择性阴离子受体:硫脲比脲衍生物的Kass值更小的原因
Chirality. 2006 Sep;18(9):762-71. doi: 10.1002/chir.20320.
4
Experimental and Theoretical Studies in Hydrogen-Bonding Organocatalysis.氢键有机催化的实验与理论研究
Molecules. 2015 Aug 26;20(9):15500-24. doi: 10.3390/molecules200915500.
5
Merging nucleophilic and hydrogen bonding catalysis: an anion binding approach to the kinetic resolution of propargylic amines.亲核催化与氢键催化的融合:一种阴离子结合策略用于炔丙胺的动力学拆分。
J Am Chem Soc. 2010 Oct 6;132(39):13624-6. doi: 10.1021/ja105337h.
6
Recognition and activation by ureas and thioureas: stereoselective reactions using ureas and thioureas as hydrogen-bonding donors.脲和硫脲的识别与活化:以脲和硫脲作为氢键供体的立体选择性反应。
Org Biomol Chem. 2005 Dec 21;3(24):4299-306. doi: 10.1039/b511216h. Epub 2005 Oct 20.
7
Bifunctional hydrogen-bond donors that bear a quinazoline or benzothiadiazine skeleton for asymmetric organocatalysis.具有喹唑啉或苯并噻二嗪骨架的双功能氢键供体,用于不对称有机催化。
Chemistry. 2011 Sep 5;17(37):10470-7. doi: 10.1002/chem.201101338. Epub 2011 Aug 2.
8
2,7-functionalized indoles as receptors for anions.作为阴离子受体的2,7-官能化吲哚
J Org Chem. 2007 Nov 9;72(23):8921-7. doi: 10.1021/jo701702p. Epub 2007 Oct 16.
9
Anion complexation and sensing using modified urea and thiourea-based receptors.采用改性脲和硫脲基受体的阴离子络合和传感。
Chem Soc Rev. 2010 Oct;39(10):3729-45. doi: 10.1039/b926160p. Epub 2010 Aug 25.
10
Double diastereocontrol in bifunctional thiourea organocatalysis: iterative Michael-Michael-Henry sequence regulated by the configuration of chiral catalysts.双非对映体控制的双功能硫脲有机催化:手性催化剂构型调控的迭代迈克尔-迈克尔-亨氏反应序列。
Org Lett. 2011 Oct 21;13(20):5416-9. doi: 10.1021/ol201559j. Epub 2011 Sep 14.

引用本文的文献

1
The impact of supramolecular self-association of organocatalysts on catalytic performance.有机催化剂的超分子自组装对催化性能的影响。
Nat Rev Chem. 2025 Sep 17. doi: 10.1038/s41570-025-00751-1.
2
Computational Identification of Potential Organocatalysts (CIPOC) Reveals a 2-aminoDMAP/Urea Catalyst Superior to Its Thiourea Analogue.潜在有机催化剂的计算识别(CIPOC)揭示了一种优于其硫脲类似物的2-氨基DMAP/尿素催化剂。
J Am Chem Soc. 2025 Mar 26;147(12):10078-10087. doi: 10.1021/jacs.4c10634. Epub 2025 Mar 11.
3
Reaction contest: hydrolysis intramolecular cyclisation reaction in alkyl squaramate esters.
反应竞争:烷基方酸酯中的水解分子内环化反应。
RSC Adv. 2024 Oct 11;14(44):32126-32132. doi: 10.1039/d4ra04362f. eCollection 2024 Oct 9.
4
Urea-Based [2]Rotaxanes as Effective Phase-Transfer Organocatalysts: Hydrogen-Bonding Cooperative Activation Enabled by the Mechanical Bond.基于尿素的[2]轮烷作为有效的相转移有机催化剂:机械键实现的氢键协同活化
J Am Chem Soc. 2024 Aug 21;146(33):22887-22892. doi: 10.1021/jacs.4c06630. Epub 2024 Jul 8.
5
A Squaramide-Based Organocatalyst as a Novel Versatile Chiral Solvating Agent for Carboxylic Acids.一种基于方酰胺的有机催化剂作为羧酸新型通用手性溶剂化剂。
Molecules. 2024 May 19;29(10):2389. doi: 10.3390/molecules29102389.
6
Assessing Squarates as Amine-Reactive Probes.评估 Squarates 作为胺反应探针。
J Am Chem Soc. 2023 Nov 22;145(46):25056-25060. doi: 10.1021/jacs.2c05691. Epub 2023 Nov 8.
7
Water-Soluble Squaramide-Functionalized Copolymers for Anion Recognition.用于阴离子识别的水溶性方酰胺功能化共聚物
Macromol Rapid Commun. 2025 Apr;46(8):e2300406. doi: 10.1002/marc.202300406. Epub 2023 Oct 2.
8
Catalytic Enantioselective Intramolecular Oxa-Michael Reaction to α,β-Unsaturated Esters and Amides.手性催化剂促进的α,β-不饱和酯和酰胺的分子内氧杂-Michael 反应。
J Am Chem Soc. 2023 Jun 14;145(23):12771-12782. doi: 10.1021/jacs.3c03182. Epub 2023 May 30.
9
Asymmetric Organocatalysis in the Remote (3 + 2)-Cycloaddition to 4-(Alk-1-en-1-yl)-3-cyanocoumarins.不对称有机催化远程(3 + 2)-环加成反应在 4-(烷基-1-烯-1-基)-3-氰基香豆素中的应用。
Org Lett. 2023 May 26;25(20):3728-3732. doi: 10.1021/acs.orglett.3c01189. Epub 2023 May 15.
10
Silver-Free Gold-Catalyzed Heterocyclizations through Intermolecular H-Bonding Activation.无银的金催化杂环化反应:通过分子间氢键活化实现。
J Org Chem. 2023 Feb 17;88(4):2487-2492. doi: 10.1021/acs.joc.2c02932. Epub 2023 Jan 26.