Tong Weijun, Zhu Yi, Wang Zhipeng, Gao Changyou, Möhwald Helmuth
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Macromol Rapid Commun. 2010 Jun 2;31(11):1015-9. doi: 10.1002/marc.200900881. Epub 2010 Apr 13.
Layer-by-layer (LbL) assembly was conducted on CaCO(3) microparticles pre-doped with polystyrene-block-poly(acrylic acid) (PS-b-PAA) micelles, and resulted in micelles encapsulation in the microcapsules after core removal. Distribution of the micelles in the templates and capsules was characterized by transmission electron microscopy and confocal laser scanning microscopy. The micelles inside the capsules connected with each other to form a chain and network-like structure with a higher density near the capsule walls. The hydrophobic PS cores were then able to load small uncharged hydrophobic drugs while the negatively charged PAA corona could induce spontaneous deposition of water-soluble positively charged drugs such as doxorubicin.
在预先掺杂有聚苯乙烯-嵌段-聚丙烯酸（PS-b-PAA）胶束的碳酸钙（CaCO₃）微粒上进行逐层（LbL）组装，去除核心后，胶束被包裹在微胶囊中。通过透射电子显微镜和共聚焦激光扫描显微镜对模板和胶囊中胶束的分布进行了表征。胶囊内的胶束相互连接形成链状和网络状结构，在胶囊壁附近密度更高。疏水性的PS核能够负载不带电荷的小分子疏水性药物，而带负电荷的PAA冠层可以诱导水溶性带正电荷的药物（如阿霉素）的自发沉积。
