Zhou Bin, Niu Li-Na, Shi Wei, Zhang Wei, Arola Dwayne D, Breschi Lorenzo, Mao Jing, Chen Ji-Hua, Pashley David H, Tay Franklin R
Tongji Hospital, Huazhong University of Science and Technology, Wuhan (PR China).
School of Stomatology, Fourth Military Medical University, Xi'an (PR China).
Adv Funct Mater. 2014 Apr 2;24(13):1895-1903. doi: 10.1002/adfm.201302920.
In this paper, we report a process for generating collagen-yttria-stabilized amorphous zirconia hybrid scaffolds by introducing acetylacetone-inhibited zirconia precursor nanodroplets into a poly(allylamine)-coated collagen matrix. This polyelectrolyte coating triggers intrafibrillar condensation of the precursors into amorphous zirconia, which is subsequently transformed into tetragonal yttria-stabilized zirconia after calcination. Our findings represent a new paradigm in the synthesis of non-naturally occurring collagen-based hybrid scaffolds under alcoholic mineralizing conditions.
在本文中，我们报道了一种通过将乙酰丙酮抑制的氧化锆前驱体纳米液滴引入聚（烯丙胺）涂层的胶原蛋白基质中来制备胶原蛋白-氧化钇稳定的非晶态氧化锆混合支架的方法。这种聚电解质涂层促使前驱体在纤维内缩合形成非晶态氧化锆，随后在煅烧后转化为四方晶系的氧化钇稳定的氧化锆。我们的研究结果代表了在醇类矿化条件下合成非天然存在的基于胶原蛋白的混合支架的一种新范例。
