Reisbick S, Neuringer M, Hasnain R, Connor W E
Department of Medicine, Oregon Health Sciences University, Portland 97201.
Physiol Behav. 1990 Feb;47(2):315-23. doi: 10.1016/0031-9384(90)90149-x.
Omega-3 fatty acids are a major component of neural membranes. They are essential nutrients for normal biochemical development of the brain and retina and may affect behavior. In our studies of long-term dietary omega-3 fatty acid deficiency, we have found a new effect of this deficiency in rhesus monkeys. Deficient monkeys visited the home cage drinking spout more frequently than controls (Experiment 1), and drank more water over 24 hours (Experiment 2). The increase in intake was mirrored by increased combined output of urine + feces over 24 hours (Experiment 3), and was not due to spillage (Experiment 4). The dietary deficiency greatly reduced omega-3 fatty acids in red blood cells but did not affect serum electrolyte levels. The changes in fluid intake and output may be related to direct or indirect effects on central or peripheral control mechanisms for drinking or excretion, which may be mediated by altered composition of neural or other membranes or changes in eicosanoid metabolism.
欧米伽-3脂肪酸是神经细胞膜的主要成分。它们是大脑和视网膜正常生化发育所必需的营养素，可能会影响行为。在我们对长期膳食欧米伽-3脂肪酸缺乏的研究中，我们在恒河猴身上发现了这种缺乏的一种新影响。缺乏欧米伽-3脂肪酸的猴子比对照组更频繁地前往笼舍饮水口（实验1），并且在24小时内饮水量更多（实验2）。摄入量的增加与24小时内尿液+粪便的总排出量增加相对应（实验3），且并非由于溢出（实验4）。膳食缺乏极大地降低了红细胞中的欧米伽-3脂肪酸，但并未影响血清电解质水平。液体摄入量和排出量的变化可能与对饮水或排泄的中枢或外周控制机制的直接或间接影响有关，这可能是由神经或其他膜的组成改变或类花生酸代谢变化介导的。
