铜介导的邻炔基苯酚与恶二唑的环化直接偶联：双杂芳基的脱氢级联构建。
Copper-mediated annulative direct coupling of o-alkynylphenols with oxadiazoles: a dehydrogenative cascade construction of biheteroaryls.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2011 Jun 17;13(12):3076-9. doi: 10.1021/ol200975j. Epub 2011 May 17.
PMID:21591623
Abstract
A copper-mediated annulative direct coupling of o-alkynylphenols with 1,3,4-oxadiazoles proceeds smoothly even under ambient conditions to afford the corresponding biheteroaryls. The reaction system represents a new avenue for the construction of biheteroaryl molecules of interest in their biological and physical properties.
摘要
铜介导的邻炔基苯酚与 1,3,4-噁二唑的环化直接偶联反应即使在环境条件下也能顺利进行，从而得到相应的双杂芳基。该反应体系为构建具有生物和物理性质的双杂芳基分子提供了新途径。
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