Kawano Tsuyoshi, Yoshizumi Tomoki, Hirano Koji, Satoh Tetsuya, Miura Masahiro
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Org Lett. 2009 Jul 16;11(14):3072-5. doi: 10.1021/ol9011212.
The copper-mediated direct arylation of 1,3,4-oxadiazoles and 1,2,4-triazoles with aryl iodides proceeds efficiently in the presence of suitable ligands and bases. This method allows the installation of a variety of aryl moieties bearing a functional group such as ketone, ester, or nitrile so as to enable the facile construction of various functionalized oxadiazole and triazole core pi systems.
在合适的配体和碱存在下，铜介导的1,3,4-恶二唑和1,2,4-三唑与芳基碘的直接芳基化反应能高效进行。该方法能够引入带有酮、酯或腈等官能团的各种芳基部分，从而便于构建各种功能化的恶二唑和三唑核心π体系。
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