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使用水热处理和微弧氧化对3D打印Ti6Al4V支架进行表面改性以增强成骨活性的比较研究。

Comparative Study on 3D Printed Ti6Al4V Scaffolds with Surface Modifications Using Hydrothermal Treatment and Microarc Oxidation to Enhance Osteogenic Activity.

作者信息

Huang Leizhen, Cai Bianyun, Huang Yong, Wang Jingcheng, Zhu Ce, Shi Kun, Song Yueming, Feng Ganjun, Liu Limin, Zhang Li

机构信息

Department of Orthopedic Surgery and Orthopedic Research Institue, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, Henan 471026, China.

出版信息

ACS Omega. 2021 Jan 7;6(2):1465-1476. doi: 10.1021/acsomega.0c05191. eCollection 2021 Jan 19.

DOI:10.1021/acsomega.0c05191
PMID:33490806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7818615/
Abstract

Titanium (Ti) and its alloys have been widely used in clinics as preferred materials for bone tissue repair and replacement. However, the lack of biological activity of Ti limits its clinical applications. Surface modification of Ti with bioactive elements has always been a research hotspot. In this study, to promote the osseointegration of Ti6Al4V (Ti64) implants, calcium (Ca), oxygen (O), and phosphorus (P) codoped multifunctional micro-nanohybrid coatings were prepared on a three-dimensional (3D) printed porous Ti64 surface by microarc oxidation (MAO) and a hydrothermal method (HT). The surface morphologies, chemical compositions, and surface/cell interactions of the obtained coatings were studied. experiments indicated that all hybrid coating-modified Ti64 implants could enhance protein adsorption and MC3T3 osteoblasts' activity, adhesion, and differentiation ability. experiments showed that the hybrid coating promoted early osseointegration. By comparison, microarc oxidation-treated Ti64 (M-Ti) has the best biological activity and the strongest ability of osseointegration. It provides important theoretical significance and potential application prospects for improving the biological activity of Ti implants.

摘要

钛（Ti）及其合金作为骨组织修复和置换的首选材料已在临床上广泛应用。然而，钛缺乏生物活性限制了其临床应用。用生物活性元素对钛进行表面改性一直是研究热点。在本研究中，为促进Ti6Al4V（Ti64）植入物的骨整合，通过微弧氧化（MAO）和水热法（HT）在三维（3D）打印的多孔Ti64表面制备了钙（Ca）、氧（O）和磷（P）共掺杂的多功能微纳混合涂层。研究了所得涂层的表面形貌、化学成分以及表面/细胞相互作用。实验表明，所有混合涂层改性的Ti64植入物均可增强蛋白质吸附以及MC3T3成骨细胞的活性、黏附能力和分化能力。实验表明，混合涂层促进了早期骨整合。相比之下，微弧氧化处理的Ti64（M-Ti）具有最佳的生物活性和最强的骨整合能力。这为提高钛植入物的生物活性提供了重要的理论意义和潜在的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9978/7818615/b6176360be85/ao0c05191_0009.jpg
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