Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Int J Hyperthermia. 2011;27(4):320-43. doi: 10.3109/02656736.2010.534527.
The purpose of this review is to summarise a literature survey on thermal thresholds for tissue damage. This review covers published literature for the consecutive years from 2002-2009. The first review on this subject was published in 2003. It included an extensive discussion of how to use thermal dosimetric principles to normalise all time-temperature data histories to a common format. This review utilises those same principles to address sensitivity of a variety of tissues, but with particular emphasis on brain and testis. The review includes new data on tissues that were not included in the original review. Several important observations have come from this review. First, a large proportion of the papers examined for this review were discarded because time-temperature history at the site of thermal damage assessment was not recorded. It is strongly recommended that future research on this subject include such data. Second, very little data is available examining chronic consequences of thermal exposure. On a related point, the time of assessment of damage after exposure is critically important for assessing whether damage is transient or permanent. Additionally, virtually no data are available for repeated thermal exposures which may occur in certain recreational or occupational activities. For purposes of regulatory guidelines, both acute and lasting effects of thermal damage should be considered.
本文旨在综述组织损伤热阈值的文献研究。本综述涵盖了 2002 年至 2009 年连续年份的已发表文献。第一篇关于该主题的综述于 2003 年发表。它广泛讨论了如何利用热剂量学原理将所有的时-温数据历史记录归一化为通用格式。本综述利用相同的原理来研究各种组织的敏感性，但特别关注大脑和睾丸。本综述包括了原始综述中未包含的新组织数据。从这次综述中得出了几个重要的观察结果。首先，由于没有记录热损伤评估部位的时-温历史，本综述检查的大部分论文都被丢弃了。强烈建议未来关于这一主题的研究纳入此类数据。其次，几乎没有关于热暴露慢性后果的研究。在相关的一点上，暴露后损伤评估的时间对于评估损伤是暂时的还是永久的至关重要。此外，几乎没有关于某些娱乐或职业活动中可能发生的重复热暴露的数据。出于监管指南的目的，应考虑热损伤的急性和持久影响。
