Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu-City, Oita, Japan.
J Gastroenterol Hepatol. 2011 Sep;26(9):1451-6. doi: 10.1111/j.1440-1746.2011.06779.x.
jhp0562 and β-(1,3)galT (jhp0563) of Helicobacter pylori have been suggested as novel virulent factors; however, the clinical associations and functions of these genes remain unclear. We examined the prevalence of jhp0562, β-(1,3)galT, and cagA in the United States (US) and Japanese populations.
A total of 308 strains (171 from the US and 137 from Japan) were examined for the status of jhp0562, β-(1,3)galT, and cagA by polymerase chain reaction.
There were significant differences in the status of jhp0562, β-(1,3)galT and cagA between the US and Japanese populations (P < 0.001). In the US, the prevalence of β-(1,3)galT was significantly lower in strains isolated from patients with duodenal ulcer (DU) or gastric ulcer (GU) than those with gastritis (47.8% and 32.1% vs 72.0%, P < 0.01), and the absence of β-(1,3)galT was an independent factor discriminating DU and GU from gastritis (adjusted odds ratios, 4.21 and 8.52; 95% confidence intervals, 1.75 to 10.12 and 2.76 to 26.33, respectively). In the US, the prevalence of the jhp0562-positive/β-(1,3)galT-negative genotype was significantly higher in strains from DU and GU patients than in those from gastritis patients (50.0%, 67.9%, and 24.4%, P < 0.01) and the cagA status was significantly correlated with that of jhp0562 and inversely correlated with that of β-(1,3)galT. In contrast, the prevalence of these three genes was not significantly different in Japan.
jhp0562 or β-(1,3)galT can be used to discriminate peptic ulcers from gastritis in the US, but not in Japan.
幽门螺杆菌的 jhp0562 和 β-(1,3)galT（jhp0563）被认为是新的毒力因子，但这些基因的临床相关性和功能仍不清楚。我们在美国（US）和日本人群中检测了 jhp0562、β-(1,3)galT 和 cagA 的流行情况。
通过聚合酶链反应检测了 308 株（美国 171 株，日本 137 株）菌株的 jhp0562、β-(1,3)galT 和 cagA 状态。
美国和日本人群中 jhp0562、β-(1,3)galT 和 cagA 的状态存在显著差异（P<0.001）。在美国，十二指肠溃疡（DU）或胃溃疡（GU）患者分离株中 β-(1,3)galT 的发生率明显低于胃炎患者（47.8%和 32.1%比 72.0%，P<0.01），β-(1,3)galT 的缺失是 DU 和 GU 与胃炎区分的独立因素（调整优势比，4.21 和 8.52；95%置信区间，1.75 至 10.12 和 2.76 至 26.33）。在美国，DU 和 GU 患者分离株的 jhp0562 阳性/β-(1,3)galT 阴性基因型的发生率明显高于胃炎患者（50.0%、67.9%和 24.4%，P<0.01），cagA 状态与 jhp0562 显著相关，与 β-(1,3)galT 呈负相关。相比之下，在日本，这三种基因的流行率没有显著差异。
在美国，jhp0562 或 β-(1,3)galT 可用于区分消化性溃疡和胃炎，但在日本不行。
