Graduate Program in Molecular Biology, Division of Basic Reproductive Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Trends Endocrinol Metab. 2011 Jun;22(6):211-7. doi: 10.1016/j.tem.2011.04.003. Epub 2011 May 17.
In many species the lactating mammary gland is one of the most lipogenic organs of the body. The majority of the lipid produced during lactation is secreted into milk by a novel process of membrane envelopment of cytoplasmic lipid droplets (CLDs). Adipophilin (ADRP/ADPH/PLIN2), a member of the perilipin (PAT) family of lipid droplet proteins, is hypothesized to play a pivotal role in both formation and secretion of milk lipids. Production of milk lipids is the only known example of CLD secretion, and the only process in which PAT family members undergo secretion. This review discusses emerging data on the structural and functional properties of adipophilin that determine its physiological actions and mediate its effects on milk lipid formation and secretion.
在许多物种中，哺乳期的乳腺是体内最具脂生成能力的器官之一。哺乳期产生的大多数脂质通过细胞质脂滴（CLD）的膜包裹的新过程分泌到乳汁中。脂滴蛋白（PAT）家族的一员脂肪分化相关蛋白（ADRP/ADPH/PLIN2）被假设在乳脂的形成和分泌中发挥关键作用。乳脂的产生是 CLD 分泌的唯一已知例子，也是 PAT 家族成员发生分泌的唯一过程。本综述讨论了关于脂肪分化相关蛋白的结构和功能特性的新数据，这些数据决定了其生理作用，并介导了其对乳脂形成和分泌的影响。
