Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
J Lipid Res. 2010 Feb;51(2):262-73. doi: 10.1194/jlr.R003582. Epub 2009 Nov 3.
Cytoplasmic lipid droplets (CLDs) are cellular structures composed of a neutral lipid core surrounded by a phospholipid monolayer of amphipathic lipids and a variety of proteins. CLDs have classically been regarded as cellular energy storage structures. However, recent proteomic studies reveal that, although many of the proteins found to associate with CLDs are connected to lipid metabolism, storage, and homeostasis, there are also proteins with no obvious connection to the classical function and typically associated with other cellular compartments. Such proteins are termed refugee proteins, and their presence suggests that CLDs may serve an expanded role as a dynamic protein storage site, providing a novel mechanism for the regulation of protein function and transport.
细胞质脂滴 (CLD) 是由中性脂质核心组成的细胞结构，周围环绕着双亲性脂质的磷脂单层和多种蛋白质。CLD 传统上被认为是细胞能量储存结构。然而，最近的蛋白质组学研究表明，尽管与 CLD 相关的许多蛋白质与脂质代谢、储存和动态平衡有关，但也有一些蛋白质与经典功能没有明显联系，通常与其他细胞区室相关。这些蛋白质被称为难民蛋白，它们的存在表明 CLD 可能作为一个动态蛋白质储存场所发挥扩展作用，为蛋白质功能和运输的调节提供了新的机制。
