Department of Animal Science, University of Padua, Viale dell'Università 12 and 16, 35020 Legnaro (PD), Italy.
Vet J. 2012 Mar;191(3):292-8. doi: 10.1016/j.tvjl.2011.04.009. Epub 2011 May 17.
Leptin and adiponectin are adipokines produced by the white adipose tissue. The adipokines have been shown to be valuable quantitative markers of adiposity in dogs. Leptin positively correlates with body condition score (BCS) in dogs, regardless of age, sex and breed, and is influenced by feeding state, pharmacological treatment and thyroid gland activity. Conversely, adiponectin negatively correlates with body fat mass and is therefore more abundant in lean animals. The implication of leptin and adiponectin in the pathogenesis of metabolic syndrome is well established in humans, but currently lacking in dogs. Additional studies are necessary to demonstrate their potential usefulness for monitoring the progression of obesity-related diseases and response to treatment. To date, measurement of canine leptin and adiponectin has been used in experimental studies only, whereas bodyweight and BCS are considered the first-approach parameters for the routine assessment of body fat content in obese dogs.
瘦素和脂联素是由白色脂肪组织产生的脂肪因子。这些脂肪因子已被证明是犬体脂的有价值的定量标志物。无论年龄、性别和品种如何，瘦素与体况评分（BCS）呈正相关，并且受喂养状态、药物治疗和甲状腺功能的影响。相反，脂联素与体脂肪量呈负相关，因此在瘦动物中更为丰富。瘦素和脂联素在人类代谢综合征发病机制中的作用已得到充分证实，但在犬中目前尚缺乏相关研究。需要进一步的研究来证明它们在监测与肥胖相关疾病的进展和治疗反应方面的潜在用途。迄今为止，犬类瘦素和脂联素的测量仅在实验研究中使用，而体重和 BCS 被认为是评估肥胖犬体脂肪含量的常规方法中的首选参数。
