Department of Clinical Sciences, Cornell University College of Veterinary Medicine, VMC 1-120, Box 34, Ithaca, NY 14853, USA.
Br J Nutr. 2011 Oct;106 Suppl 1:S11-4. doi: 10.1017/S0007114511000560.
Evidence suggests that adipose tissue-derived adipokines induce mild inflammation and may play a role in insulin resistance associated with diabetes. The present study was designed to examine a series of adipokines and markers of inflammation in dogs before and after a successful weight loss. The study included fasting serum samples from twenty-five dogs before and after a weight-loss programme. Serum C-reactive protein (CRP) and monocyte chemoattractant protein-1 (MCP-1) were measured as indicators of chronic inflammation, while serum adipokines including total adiponectin, high-molecular-weight (HMW) adiponectin, resistin and leptin were also examined. Medians for CRP (before, 10.0 (interquartile range 5.4-15.0) μg/ml; after, 5.6 (interquartile range 3.8-7.0) μg/ml) and MCP-1 (before, 212 (interquartile range 157-288) ng/ml; after, 185 (interquartile range 143-215) ng/ml) decreased significantly after weight loss. Medians for resistin showed a mild, yet significant reduction (before, 67.1 (interquartile range 44.4-88.5) pg/ml; after, 60.5 (interquartile range 32.3-67.1) pg/ml), while leptin showed a dramatic decrease after weight loss (before, 18.9 (interquartile range 10.8-35.4) ng/ml; after, 6.6 (interquartile range 3.9-10.2) ng/ml). Serum total adiponectin and HMW adiponectin were unchanged on all analyses performed. These data suggest that weight loss can decrease chronic inflammation; however, the clinical implications of this decrease are not well elucidated in dogs. Surprisingly, there was no increase in total or HMW serum adiponectin after weight loss, as observed previously in human subjects. The lack of change in total and HMW adiponectin might explain why insulin resistance and type 2 diabetes are less prevalent in obese dogs when compared with humans and cats.
有证据表明，脂肪组织来源的脂肪因子会引起轻微的炎症，并可能在与糖尿病相关的胰岛素抵抗中发挥作用。本研究旨在观察成功减肥前后一系列犬类的脂肪因子和炎症标志物。研究纳入了 25 只狗在减肥计划前后的空腹血清样本。血清 C 反应蛋白（CRP）和单核细胞趋化蛋白-1（MCP-1）被用作慢性炎症的指标，同时还检测了血清脂肪因子，包括总脂联素、高分子量（HMW）脂联素、抵抗素和瘦素。CRP（减肥前：10.0（四分位距 5.4-15.0）μg/ml；减肥后：5.6（四分位距 3.8-7.0）μg/ml）和 MCP-1（减肥前：212（四分位距 157-288）ng/ml；减肥后：185（四分位距 143-215）ng/ml）在减肥后显著降低。抵抗素的中位数略有下降（减肥前：67.1（四分位距 44.4-88.5）pg/ml；减肥后：60.5（四分位距 32.3-67.1）pg/ml），而瘦素在减肥后显著下降（减肥前：18.9（四分位距 10.8-35.4）ng/ml；减肥后：6.6（四分位距 3.9-10.2）ng/ml）。所有分析均显示血清总脂联素和 HMW 脂联素无变化。这些数据表明，减肥可以减轻慢性炎症；然而，这种减少在犬类中的临床意义尚不清楚。令人惊讶的是，减肥后总脂联素和 HMW 脂联素并没有增加，这与以前在人类研究中观察到的结果相反。总脂联素和 HMW 脂联素没有变化可能解释了为什么与人类和猫相比，肥胖犬的胰岛素抵抗和 2 型糖尿病的发病率较低。
