Vázquez-Reta J A, Jiménez Ferrer M C, Colunga-Sánchez A, Pizarro-Chávez S, Vázquez-Guerrero A L, Vázquez-Guerrero A R
Servicio de Endoscopia, Hospital Central Universitario, Universidad Autónoma de Chihuahua, Chihuahua, México.
Rev Gastroenterol Mex. 2011 Jan-Mar;76(1):13-8.
The diagnostic upper gastrointestinal endoscopy (UGI) is a safe procedure although 50% to 60% morbidity and mortality due to cardiopulmonary complications.
To compare safety and efficacy of dexmedetomidine vs. midazolam in UGI.
We conducted a randomized controlled, double-blind, clinical trial to compare the two drugs. Patients with an indication of UGI were randomized to receive sedation with dexmedetomidine or midazolam during the procedure. We compared age, sex, physical status (ASA), body mass index (BMI), degree of sedation (Ramsay scale), recovery time and degree of satisfaction with the procedure.
Forty patients with an indication of UGI were included (20 in each arm). Both groups showed a similar distribution by sex, age, BMI and ASA physical status. The level of sedation was similar starting and ending the procedure according to the Ramsay scale. The dexmedetomidine group had a shorter recovery time (7.1 vs. 15.8 min, p <0.05) and satisfaction (9.9 vs. 9.0, p <0.05). Adverse effects occurred in similar proportions in both groups.
Midazolam and dexmedetomidine are suitable for endoscopic procedures of upper digestive tract. Dexmedetomidine offers shorter recovery time and better patient's satisfaction.
诊断性上消化道内镜检查（UGI）是一种安全的操作，尽管有50%至60%的患者会因心肺并发症出现发病和死亡情况。
比较右美托咪定与咪达唑仑在上消化道内镜检查中的安全性和有效性。
我们进行了一项随机对照双盲临床试验来比较这两种药物。有上消化道内镜检查指征的患者在检查过程中被随机分配接受右美托咪定或咪达唑仑镇静。我们比较了年龄、性别、身体状况（ASA）、体重指数（BMI）、镇静程度（ Ramsay量表）、恢复时间以及对检查的满意度。
纳入了40例有上消化道内镜检查指征的患者（每组20例）。两组在性别、年龄、BMI和ASA身体状况方面分布相似。根据Ramsay量表，在检查开始和结束时镇静水平相似。右美托咪定组的恢复时间更短（7.1分钟对15.8分钟，p<0.05），满意度更高（9.9对9.0，p<0.05）。两组不良反应发生率相似。
咪达唑仑和右美托咪定适用于上消化道内镜检查。右美托咪定恢复时间更短，患者满意度更高。
