水痘-带状疱疹病毒 DNA 在接种部位和接种 Zostavax 疫苗后唾液中的存在。
Varicella zoster virus DNA at inoculation sites and in saliva after Zostavax immunization.
机构信息
Space Life Sciences, NASA, Lyndon B Johnson Space Center, Houston, Texas, USA.
出版信息
J Infect Dis. 2011 Jun 1;203(11):1542-5. doi: 10.1093/infdis/jir139.
Abstract
Analysis of 36 individuals over age 60 years who were immunized with Zostavax revealed varicella zoster virus (VZV) DNA in swabs of skin inoculation sites obtained immediately after immunization in 18 (50%) of 36 subjects (copy number per nanogram of total DNA, 28 to 2.1 × 10(6)) and in saliva collected over 28 days in 21 (58%) of 36 subjects (copy number, 20 to 248). Genotypic analysis of DNA extracted from 9 random saliva samples identified vaccine virus in all instances. In some immunized individuals over age 60, vaccine virus DNA is shed in saliva up to 4 weeks.
摘要
对 36 名 60 岁以上个体进行分析，这些个体在接种 Zostavax 后，18 名（50%）个体的皮肤接种部位拭子中立即检测到水痘带状疱疹病毒（VZV）DNA（每纳克总 DNA 的拷贝数，28 至 2.1×10(6)），21 名（58%）个体的唾液在 28 天内采集（拷贝数，20 至 248）。从 9 份随机唾液样本中提取的 DNA 的基因分析在所有情况下均鉴定出疫苗病毒。在一些 60 岁以上的免疫个体中，疫苗病毒 DNA 在唾液中排出长达 4 周。
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