在接种带状疱疹疫苗的免疫功能正常受种者中，由疫苗株水痘-带状疱疹病毒引起的带状疱疹
Herpes zoster caused by vaccine-strain varicella zoster virus in an immunocompetent recipient of zoster vaccine.
作者信息
Tseng Hung Fu, Schmid D Scott, Harpaz Rafael, LaRussa Philip, Jensen Nancy J, Rivailler Pierre, Radford Kay, Folster Jennifer, Jacobsen Steven J
机构信息
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
出版信息
Clin Infect Dis. 2014 Apr;58(8):1125-8. doi: 10.1093/cid/ciu058. Epub 2014 Jan 26.
Abstract
We report the first laboratory-documented case of herpes zoster caused by the attenuated varicella zoster virus (VZV) contained in Zostavax in a 68-year-old immunocompetent adult with strong evidence of prior wild-type VZV infection. The complete genome sequence of the isolate revealed that the strain carried 15 of 42 (36%) recognized varicella vaccine-associated single-nucleotide polymorphisms, including all 5 of the fixed vaccine markers present in nearly all of the strains in the vaccine. The case of herpes zoster was relatively mild and resolved without complications.
摘要
我们报告了首例实验室确诊的由Zostavax中减毒水痘带状疱疹病毒（VZV）引起的带状疱疹病例，患者为一名68岁免疫功能正常的成年人，有充分证据表明其既往曾感染野生型VZV。分离株的全基因组序列显示，该毒株携带了42个（36%）已识别的水痘疫苗相关单核苷酸多态性中的15个，包括疫苗中几乎所有毒株都存在的5个固定疫苗标记。该带状疱疹病例相对较轻，未出现并发症即痊愈。
相似文献
1
Herpes zoster caused by vaccine-strain varicella zoster virus in an immunocompetent recipient of zoster vaccine.在接种带状疱疹疫苗的免疫功能正常受种者中，由疫苗株水痘-带状疱疹病毒引起的带状疱疹
Clin Infect Dis. 2014 Apr;58(8):1125-8. doi: 10.1093/cid/ciu058. Epub 2014 Jan 26.
2
Vaccine-strain varicella zoster virus causing recurrent herpes zoster in an immunocompetent 2-year-old.疫苗株水痘带状疱疹病毒在一名免疫功能正常的2岁儿童中引发复发性带状疱疹。
Pediatr Infect Dis J. 2008 Sep;27(9):847-8. doi: 10.1097/INF.0b013e318170af75.
3
Vaccine-strain herpes zoster found in the trigeminal nerve area in a healthy child: A case report.健康儿童三叉神经区域发现疫苗株带状疱疹：一例报告
J Clin Virol. 2016 Dec;85:44-47. doi: 10.1016/j.jcv.2016.10.022. Epub 2016 Nov 3.
4
Herpes zoster by reactivated vaccine varicella zoster virus in a healthy child.一名健康儿童因水痘带状疱疹病毒再激活而患带状疱疹。
Eur J Pediatr. 2002 Aug;161(8):442-4. doi: 10.1007/s00431-002-0981-1. Epub 2002 Jun 25.
5
Genomic analysis of varicella-zoster virus: primers for individual open reading frames.水痘-带状疱疹病毒的基因组分析：单个开放阅读框的引物
J Clin Virol. 2003 Sep;28(1):104-10. doi: 10.1016/s1386-6532(03)00073-8.
6
Recurrent herpes zoster in the Shingles Prevention Study: Are second episodes caused by the same varicella-zoster virus strain?带状疱疹预防研究中的复发性带状疱疹：第二波发作是否由同一水痘带状疱疹病毒株引起？
Vaccine. 2020 Jan 10;38(2):150-157. doi: 10.1016/j.vaccine.2019.10.038. Epub 2019 Nov 1.
7
New method of differentiating wild-type varicella-zoster virus (VZV) strains from Oka varicella vaccine strain by VZV ORF 6-based PCR and restriction fragment length polymorphism analysis.通过基于水痘带状疱疹病毒（VZV）开放阅读框6的聚合酶链反应（PCR）和限制性片段长度多态性分析，区分野生型水痘带状疱疹病毒（VZV）毒株与Oka水痘疫苗毒株的新方法。
J Clin Virol. 2004 Feb;29(2):113-9. doi: 10.1016/s1386-6532(03)00112-4.
8
DNA sequence variability in isolates recovered from patients with postvaccination rash or herpes zoster caused by Oka varicella vaccine.从接种水痘疫苗后出疹或患带状疱疹的患者中分离出的毒株的DNA序列变异性。
J Infect Dis. 2007 Feb 15;195(4):502-10. doi: 10.1086/510532. Epub 2007 Jan 10.
9
Pediatric vaccine-strain herpes zoster: a case series.儿童疫苗株带状疱疹：病例系列
Pediatr Dermatol. 2017 Nov;34(6):665-667. doi: 10.1111/pde.13265. Epub 2017 Sep 25.
10
Improved identification and differentiation of varicella-zoster virus (VZV) wild-type strains and an attenuated varicella vaccine strain using a VZV open reading frame 62-based PCR.使用基于水痘带状疱疹病毒开放阅读框62的聚合酶链反应（PCR）改进水痘带状疱疹病毒（VZV）野生型毒株和减毒水痘疫苗毒株的鉴定与区分。
J Clin Microbiol. 2000 Sep;38(9):3156-60. doi: 10.1128/JCM.38.9.3156-3160.2000.
引用本文的文献
1
Research Progress on Varicella-Zoster Virus Vaccines.水痘带状疱疹病毒疫苗的研究进展
Vaccines (Basel). 2025 Jul 4;13(7):730. doi: 10.3390/vaccines13070730.
2
Knowledge, Attitudes, and Practices Related to Zoster Vaccination in Riyadh First Health Care Cluster in Saudi Arabia.沙特阿拉伯利雅得第一医疗保健集群中与带状疱疹疫苗接种相关的知识、态度和实践
Cureus. 2025 Jun 11;17(6):e85743. doi: 10.7759/cureus.85743. eCollection 2025 Jun.
3
Insights into pathologic mechanisms occurring during serious adverse events following live zoster vaccination.对带状疱疹活疫苗接种后严重不良事件发生过程中病理机制的见解。
J Virol. 2025 Feb 25;99(2):e0181624. doi: 10.1128/jvi.01816-24. Epub 2025 Jan 17.
4
Association Between Child Varicella Vaccination and Zoster in Household Adults: A Retrospective Japanese Cohort Study.儿童水痘疫苗接种与家庭成年成员带状疱疹之间的关联：一项日本回顾性队列研究
Acta Paediatr. 2025 Jun;114(6):1392-1398. doi: 10.1111/apa.17582. Epub 2025 Jan 13.
5
Ocular effects caused by viral infections and corresponding vaccines: An overview of varicella zoster virus, measles virus, influenza viruses, hepatitis B virus, and SARS-CoV-2.病毒感染及相应疫苗引起的眼部效应：水痘带状疱疹病毒、麻疹病毒、流感病毒、乙型肝炎病毒及严重急性呼吸综合征冠状病毒2概述
Front Med (Lausanne). 2022 Oct 26;9:999251. doi: 10.3389/fmed.2022.999251. eCollection 2022.
6
Antiviral Targeting of Varicella Zoster Virus Replication and Neuronal Reactivation Using CRISPR/Cas9 Cleavage of the Duplicated Open Reading Frames 62/71.利用 CRISPR/Cas9 切割重复的开放阅读框 62/71 实现抗病毒靶向水痘带状疱疹病毒复制和神经元再激活
Viruses. 2022 Feb 12;14(2):378. doi: 10.3390/v14020378.
7
Herpes zoster following COVID-19 vaccination in an immunocompetent and vaccinated for herpes zoster adult: A two-vaccine related event?在一名免疫功能正常且已接种带状疱疹疫苗的成年人中，新冠病毒疫苗接种后发生带状疱疹：这是一种与两种疫苗相关的事件吗？
Metabol Open. 2022 Mar;13:100171. doi: 10.1016/j.metop.2022.100171. Epub 2022 Feb 10.
8
Advances and Perspectives in the Management of Varicella-Zoster Virus Infections.水痘-带状疱疹病毒感染管理的进展与展望。
Molecules. 2021 Feb 20;26(4):1132. doi: 10.3390/molecules26041132.
9
Generalized Rash and Bilateral Retinal Necrosis in an Adult Healthcare Worker after Post-Exposure Herpes Zoster Vaccination: A Rare Case Report.一名成年医护人员接种带状疱疹暴露后疫苗后出现全身性皮疹和双侧视网膜坏死：一例罕见病例报告
Kans J Med. 2020 Dec 11;13:324-325. doi: 10.17161/kjm.vol13.13808. eCollection 2020.
10
Varicella Vaccine Meningitis as a Complication of Herpes Zoster in Twice-Immunized Immunocompetent Adolescents.水痘疫苗相关性带状疱疹脑炎：免疫功能正常青少年二次免疫后的并发症
J Child Neurol. 2020 Nov;35(13):889-895. doi: 10.1177/0883073820938597. Epub 2020 Jul 17.
本文引用的文献
1
Deep sequencing of viral genomes provides insight into the evolution and pathogenesis of varicella zoster virus and its vaccine in humans.对病毒基因组进行深度测序可深入了解人类水痘带状疱疹病毒及其疫苗的进化和发病机制。
Mol Biol Evol. 2014 Feb;31(2):397-409. doi: 10.1093/molbev/mst210. Epub 2013 Oct 25.
2
Incidence and clinical characteristics of herpes zoster among children in the varicella vaccine era, 2005-2009.2005-2009 年水痘疫苗时代儿童带状疱疹的发病率和临床特征。
J Infect Dis. 2013 Dec 1;208(11):1859-68. doi: 10.1093/infdis/jit405. Epub 2013 Aug 6.
3
Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study.带状疱疹疫苗对美国老年人群中带状疱疹和带状疱疹后神经痛的有效性：一项队列研究。
PLoS Med. 2013;10(4):e1001420. doi: 10.1371/journal.pmed.1001420. Epub 2013 Apr 9.
4
Latency of varicella zoster virus in dorsal root, cranial, and enteric ganglia in vaccinated children.接种疫苗儿童中水痘带状疱疹病毒在背根神经节、颅神经节和肠神经节中的潜伏情况。
Trans Am Clin Climatol Assoc. 2012;123:17-33; discussion 33-5.
5
Predicting the functional effect of amino acid substitutions and indels.预测氨基酸替换和缺失的功能效应。
PLoS One. 2012;7(10):e46688. doi: 10.1371/journal.pone.0046688. Epub 2012 Oct 8.
6
Herpes zoster vaccine in older adults and the risk of subsequent herpes zoster disease.老年人带状疱疹疫苗与后续带状疱疹发病风险。
JAMA. 2011 Jan 12;305(2):160-6. doi: 10.1001/jama.2010.1983.
7
A proposal for a common nomenclature for viral clades that form the species varicella-zoster virus: summary of VZV Nomenclature Meeting 2008, Barts and the London School of Medicine and Dentistry, 24-25 July 2008.用于形成水痘-带状疱疹病毒（varicella-zoster virus）种的病毒进化枝的通用命名法建议：2008 年 7 月 24 日至 25 日在 Barts 和伦敦医学院举行的 VZV 命名法会议摘要。
J Gen Virol. 2010 Apr;91(Pt 4):821-8. doi: 10.1099/vir.0.017814-0. Epub 2010 Jan 13.
8
The safety profile of varicella vaccine: a 10-year review.水痘疫苗的安全性概况：十年回顾
J Infect Dis. 2008 Mar 1;197 Suppl 2:S165-9. doi: 10.1086/522125.
9
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.一种预防老年人带状疱疹及带状疱疹后神经痛的疫苗。
N Engl J Med. 2005 Jun 2;352(22):2271-84. doi: 10.1056/NEJMoa051016.
10
Varicella in Americans from NHANES III: implications for control through routine immunization.来自美国国家健康和营养检查调查（NHANES）III的美国人中的水痘：通过常规免疫进行控制的意义。
J Med Virol. 2003;70 Suppl 1:S111-8. doi: 10.1002/jmv.10364.
Zotero 插件