Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20852-9411, USA.
J Neurosci. 2011 May 18;31(20):7402-11. doi: 10.1523/JNEUROSCI.6250-10.2011.
The striatum has important roles in motor control and action learning and, like many brain regions, receives multiple monoaminergic inputs. We have examined serotonergic modulation of rat and mouse corticostriatal neurotransmission and find that serotonin (5-HT) activates 5-HT(1b) receptors resulting in a long-term depression (LTD) of glutamate release and striatal output that we have termed 5-HT-LTD. 5-HT-LTD is presynaptically mediated, cAMP pathway dependent, and inducible by endogenous striatal 5-HT, as revealed by application of a selective 5-HT reuptake inhibitor. 5-HT-LTD is mutually occlusive with dopamine/endocannabinoid-dependent LTD, suggesting that these two forms of LTD act on the same corticostriatal terminals. Thus, serotonergic and dopaminergic mechanisms exist that may interact to persistently sculpt corticostriatal circuits, potentially influencing action learning and striatal-based disorders.
纹状体在运动控制和动作学习中起着重要作用，与许多大脑区域一样，它接收多种单胺能输入。我们已经研究了 5-羟色胺（5-HT）对大鼠和小鼠皮质纹状体神经传递的调制作用，发现 5-HT 激活 5-HT1b 受体，导致谷氨酸释放和纹状体输出的长时程抑制（LTD），我们称之为 5-HT-LTD。5-HT-LTD 是突触前介导的，cAMP 通路依赖性的，并且可以通过内源性纹状体 5-HT 诱导，如通过应用选择性 5-HT 再摄取抑制剂所揭示的。5-HT-LTD 与多巴胺/内源性大麻素依赖性 LTD 相互排斥，表明这两种形式的 LTD 作用于相同的皮质纹状体末端。因此，存在可能相互作用以持续塑造皮质纹状体回路的 5-羟色胺能和多巴胺能机制，可能影响动作学习和基于纹状体的疾病。
