Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
J Alzheimers Dis. 2011;26(1):135-42. doi: 10.3233/JAD-2011-110038.
The aim of this study was to predict cognitive performance on the basis of the cerebrospinal fluid (CSF) biomarkers total tau (T-tau) and amyloid-β₄₂ (Aβ₄₂) in controls and patients at various impairment levels. Previous studies have found an association of CSF T-tau levels with cognitive symptoms, but it has been difficult to relate Aβ to cognition, and it has thus been hypothesized that Aβ reaches a plateau level prior to cognitive symptoms. A comprehensive battery of neuropsychological tests was subjected to factor analysis to yield aggregated cognitive domains. Linear regression models were performed for the total sample of the Gothenburg MCI study (n = 435) and for each level of impairment. Aβ₄₂ and T-tau accounted for a significant proportion of performance in all cognitive domains in the total sample. In controls (n = 60) and patients with subjective cognitive impairment (n = 105), Aβ₄₂ predicted a significant proportion of semantic and working memory performance. For patients with mild cognitive impairment (n = 170), T-tau had the most pronounced impact across cognitive domains, and more specifically on episodic memory, visuospatial, and speed/executive performance. For patients with dementia (n = 100), the most pronounced impacts of Aβ₄₂ were found in episodic memory and visuospatial functioning, while T-tau was substantially associated with episodic memory. Our results suggest that cognition is related to CSF biomarkers regardless of impairment level. Aβ₄₂ is associated with cognitive functions from a potentially early to a later disease phase, and T-tau is more indicative of performance in a later disease phase.
本研究旨在基于脑脊液（CSF）生物标志物总 tau（T-tau）和淀粉样蛋白-β₄₂（Aβ₄₂）预测认知表现，研究对象为不同损伤程度的对照组和患者。先前的研究发现 CSF T-tau 水平与认知症状相关，但 Aβ 与认知的关系一直难以确定，因此有人假设 Aβ 在认知症状出现之前达到平台水平。采用神经心理学综合测试对认知域进行因子分析。对哥德堡轻度认知障碍研究（n = 435）的总样本和每个损伤水平进行线性回归模型分析。Aβ₄₂ 和 T-tau 在总样本的所有认知域中均占表现的显著比例。在对照组（n = 60）和主观认知障碍患者（n = 105）中，Aβ₄₂ 预测了语义和工作记忆表现的显著比例。对于轻度认知障碍患者（n = 170），T-tau 在认知域中具有最显著的影响，尤其是在情景记忆、视空间和速度/执行功能方面。对于痴呆患者（n = 100），Aβ₄₂ 对情景记忆和视空间功能的影响最为显著，而 T-tau 与情景记忆有显著相关性。我们的研究结果表明，认知与 CSF 生物标志物相关，无论损伤程度如何。Aβ₄₂ 与疾病早期到晚期的认知功能相关，而 T-tau 更能反映疾病晚期的表现。
