Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX, USA.
EMBO J. 2011 May 18;30(10):1880-1. doi: 10.1038/emboj.2011.132.
EMBO J 30 10, 1990–2007 (2011); published online April 05 2011 Since the beginning of micro-RNA (miR) research, several attempts have been made to identify the ‘melano-miRs’, which are involved in melanoma progression. Indeed, a small number of miRs have been identified to regulate some genes involved in melanogenesis. However, the miRs that control the pathway to the malignant phenotype are yet undescribed. In this issue of the , Penna et al (2011) demonstrate that miR-214 is overexpressed in metastatic melanoma cell lines and tumour specimens. miR-214 regulates the expression of two transcription factors AP-2γ (directly) and AP-2α (indirectly). These transcription factors, particularly AP-2α, have been previously shown to play major roles in melanoma metastasis via regulation of genes involved in extravasation, invasion and angiogenesis. As such, this study has identified miR-214 as a driver of melanoma metastasis.
EMBO J 30 10, 1990–2007 (2011); published online April 05 2011 自 micro-RNA (miR) 研究开始以来，人们已经尝试确定参与黑色素瘤进展的“黑素 miR”。事实上，已经确定了少数 miR 来调节一些参与黑色素生成的基因。然而，控制恶性表型途径的 miR 尚未被描述。在本期的 中，Penna 等人（2011）表明，miR-214 在转移性黑色素瘤细胞系和肿瘤标本中过度表达。miR-214 调节转录因子 AP-2γ（直接）和 AP-2α（间接）的表达。这些转录因子，特别是 AP-2α，先前已被证明通过调节参与外渗、侵袭和血管生成的基因在黑色素瘤转移中发挥主要作用。因此，这项研究确定了 miR-214 是黑色素瘤转移的驱动因素。
