• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

FGFR1扩增型肺癌中miR-214-3p与FGFR1之间的相互调节机制

Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer.

作者信息

Yang Ying, Li Ziming, Yuan Hong, Ji Wenxiang, Wang Kaixuan, Lu Tingting, Yu Yongfeng, Zeng Qingyu, Li Fan, Xia Weiliang, Lu Shun

机构信息

Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, West Huaihai Road 241, 20030, Shanghai, China.

School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Huashan Road 1954, 200030, Shanghai, China.

出版信息

Oncogenesis. 2019 Sep 6;8(9):50. doi: 10.1038/s41389-019-0151-1.

DOI:10.1038/s41389-019-0151-1
PMID:31492847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6731303/
Abstract

MicroRNA (miRNA) and fibroblast growth factor receptor 1 (FGFR1) dysregulation are considered to play an important role in tumor proliferation, invasion, and metastasis. However, the regulatory mechanism between miRNAs and FGFR1 in lung cancer remains unclear and extremely critical. miR-214-3p was sharply decreased and showed a significantly negative correlation with FGFR1 in lung cancer patients (n = 30). Luciferase reporter assay confirmed that miR-214-3p could downregulate FGFR1 by directly targeting 3'-untranslated region (UTR). miR-214-3p inhibited the processes of epithelial-mesenchymal transition and Wnt/MAPK/AKT (Wnt/mitogen-activated protein kinase/AKT) signaling pathway by targeting FGFR1. Moreover, miR-214-3p not only established a negative feedback regulation loop with FGFR1 through ERK (extracellular signal-regulated kinase) but also developed a synergism with FGFR1 inhibitor AZD4547. In conclusion, our study demonstrated the regulatory mechanism between miR-214-3p and FGFR1 in lung cancer. miR-214-3p acts as a vital target in FGFR1-amplified lung cancer by forming a miR-214-3p-FGFR1-Wnt/MAPK/AKT signaling pathway network. Co-targeting miR-214-3p and FGFR1 could provide greater benefits to patients with FGFR1-amplified lung cancer.

摘要

微小RNA（miRNA）和成纤维细胞生长因子受体1（FGFR1）失调被认为在肿瘤增殖、侵袭和转移中起重要作用。然而，miRNA与FGFR1在肺癌中的调控机制仍不清楚且极其关键。在肺癌患者（n = 30）中，miR-214-3p显著降低，且与FGFR1呈显著负相关。荧光素酶报告基因检测证实，miR-214-3p可通过直接靶向3'-非翻译区（UTR）下调FGFR1。miR-214-3p通过靶向FGFR1抑制上皮-间质转化和Wnt/MAPK/AKT（Wnt/丝裂原活化蛋白激酶/AKT）信号通路的过程。此外，miR-214-3p不仅通过细胞外信号调节激酶（ERK）与FGFR1建立了负反馈调节环，还与FGFR1抑制剂AZD4547产生协同作用。总之，我们的研究揭示了miR-214-3p与FGFR1在肺癌中的调控机制。miR-214-3p通过形成miR-214-3p-FGFR1-Wnt/MAPK/AKT信号通路网络，在FGFR1扩增的肺癌中发挥重要作用。共同靶向miR-214-3p和FGFR1可为FGFR1扩增的肺癌患者带来更大益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/bef4953521ef/41389_2019_151_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/faeafef69aec/41389_2019_151_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/3bc5f5057ddb/41389_2019_151_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/56b11f730a2e/41389_2019_151_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/57fec81e60b1/41389_2019_151_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/07a51a1ef610/41389_2019_151_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/7aefa5b36eec/41389_2019_151_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/bef4953521ef/41389_2019_151_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/faeafef69aec/41389_2019_151_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/3bc5f5057ddb/41389_2019_151_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/56b11f730a2e/41389_2019_151_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/57fec81e60b1/41389_2019_151_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/07a51a1ef610/41389_2019_151_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/7aefa5b36eec/41389_2019_151_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fce5/6731303/bef4953521ef/41389_2019_151_Fig7_HTML.jpg

相似文献

1
Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer.FGFR1扩增型肺癌中miR-214-3p与FGFR1之间的相互调节机制
Oncogenesis. 2019 Sep 6;8(9):50. doi: 10.1038/s41389-019-0151-1.
2
MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway.微小RNA-330-3p通过激活丝裂原活化蛋白激酶/细胞外信号调节激酶（MAPK/ERK）信号通路，作用于谷氨酸受体离子otropic AMPA 3型（GRIA3），从而促进非小细胞肺癌的细胞侵袭和转移。
J Hematol Oncol. 2017 Jun 19;10(1):125. doi: 10.1186/s13045-017-0493-0.
3
Downregulation of N-Acetylglucosaminyltransferase GCNT3 by miR-302b-3p Decreases Non-Small Cell Lung Cancer (NSCLC) Cell Proliferation, Migration and Invasion.miR-302b-3p对N-乙酰葡糖胺基转移酶GCNT3的下调作用可降低非小细胞肺癌（NSCLC）细胞的增殖、迁移和侵袭能力。
Cell Physiol Biochem. 2018;50(3):987-1004. doi: 10.1159/000494482. Epub 2018 Oct 24.
4
MiR-454-3p-Mediated Wnt/β-catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis.miR-454-3p 通过调控 Wnt/β-catenin 信号通路抑制物促进乳腺癌转移。
Theranostics. 2019 Jan 1;9(2):449-465. doi: 10.7150/thno.29055. eCollection 2019.
5
MiR-514a-3p inhibits cell proliferation and epithelial-mesenchymal transition by targeting EGFR in clear cell renal cell carcinoma.微小RNA-514a-3p通过靶向表皮生长因子受体抑制透明细胞肾细胞癌的细胞增殖和上皮-间质转化。
Am J Transl Res. 2017 Dec 15;9(12):5332-5346. eCollection 2017.
6
FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer.FGFR1-ERK1/2-SOX2 轴促进 FGFR1 扩增型肺癌中的细胞增殖、上皮-间充质转化和转移。
Oncogene. 2018 Sep;37(39):5340-5354. doi: 10.1038/s41388-018-0311-3. Epub 2018 Jun 1.
7
MiR-19a-3p regulates the Forkhead box F2-mediated Wnt/β-catenin signaling pathway and affects the biological functions of colorectal cancer cells.miR-19a-3p 通过调控叉头框 F2 介导的 Wnt/β-catenin 信号通路影响结直肠癌细胞的生物学功能。
World J Gastroenterol. 2020 Feb 14;26(6):627-644. doi: 10.3748/wjg.v26.i6.627.
8
Regulation of brachyury by fibroblast growth factor receptor 1 in lung cancer.成纤维细胞生长因子受体1对肺癌中短尾相关蛋白的调控作用
Oncotarget. 2016 Dec 27;7(52):87124-87135. doi: 10.18632/oncotarget.13547.
9
MiR-101-3p inhibits the growth and metastasis of non-small cell lung cancer through blocking PI3K/AKT signal pathway by targeting MALAT-1.miR-101-3p 通过靶向 MALAT-1 阻断 PI3K/AKT 信号通路抑制非小细胞肺癌的生长和转移。
Biomed Pharmacother. 2017 Sep;93:1065-1073. doi: 10.1016/j.biopha.2017.07.005. Epub 2017 Jul 18.
10
miR-516a-3p inhibits breast cancer cell growth and EMT by blocking the Pygo2/Wnt signalling pathway.miR-516a-3p 通过阻断 Pygo2/Wnt 信号通路抑制乳腺癌细胞生长和 EMT。
J Cell Mol Med. 2019 Sep;23(9):6295-6307. doi: 10.1111/jcmm.14515. Epub 2019 Jul 5.

引用本文的文献

1
Role of miRNA‑214‑3p in cancer (Review).微小RNA-214-3p在癌症中的作用（综述）
Oncol Rep. 2025 Oct;54(4). doi: 10.3892/or.2025.8957. Epub 2025 Aug 1.
2
The Role of p66Shc in Cancer: Molecular Mechanisms and Therapeutic Implications.p66Shc在癌症中的作用：分子机制与治疗意义
J Cell Mol Med. 2025 Jul;29(14):e70737. doi: 10.1111/jcmm.70737.
3
MicroRNAs as Sensitizers of Tyrosine Kinase Inhibitor Resistance in Cancer: Small Molecule Partnerships.微小RNA作为癌症中酪氨酸激酶抑制剂耐药的增敏剂：小分子合作伙伴关系

本文引用的文献

1
Long noncoding RNA HOTAIR knockdown inhibits autophagy and epithelial-mesenchymal transition through the Wnt signaling pathway in radioresistant human cervical cancer HeLa cells.长链非编码 RNA HOTAIR 敲低通过 Wnt 信号通路抑制耐放射人宫颈癌 HeLa 细胞自噬和上皮-间充质转化。
J Cell Physiol. 2019 Apr;234(4):3478-3489. doi: 10.1002/jcp.26828. Epub 2018 Oct 26.
2
FEZF1-AS1 is a key regulator of cell cycle, epithelial-mesenchymal transition and Wnt/β-catenin signaling in nasopharyngeal carcinoma cells.FEZF1-AS1 是鼻咽癌细胞中细胞周期、上皮-间充质转化和 Wnt/β-连环蛋白信号通路的关键调节因子。
Biosci Rep. 2019 Jan 8;39(1). doi: 10.1042/BSR20180906. Print 2019 Jan 31.
3
Pharmaceuticals (Basel). 2025 Mar 28;18(4):492. doi: 10.3390/ph18040492.
4
Extramural venous invasion in gastric cancer: 9.4T magnetic resonance imaging assessment and circular RNA functional analysis.胃癌壁外静脉侵犯：9.4T磁共振成像评估及环状RNA功能分析
World J Gastroenterol. 2025 Apr 14;31(14):99897. doi: 10.3748/wjg.v31.i14.99897.
5
Obesity promotes immunotherapy efficacy by up-regulating the glycolytic-mediated histone lactacylation modification of CD8+ T cells.肥胖通过上调糖酵解介导的CD8+T细胞组蛋白乳酰化修饰来促进免疫治疗效果。
Front Pharmacol. 2025 Mar 5;16:1533464. doi: 10.3389/fphar.2025.1533464. eCollection 2025.
6
Unveiling the shared genes between systemic sclerosis and lung cancer.揭示系统性硬化症和肺癌之间的共同基因。
Front Med (Lausanne). 2024 Dec 18;11:1431642. doi: 10.3389/fmed.2024.1431642. eCollection 2024.
7
Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer.Wnt/β-catenin 信号通路在非小细胞肺癌发生发展及治疗抵抗中的作用
J Transl Med. 2024 Jun 13;22(1):565. doi: 10.1186/s12967-024-05380-8.
8
circNINL facilitates aerobic glycolysis, proliferation, invasion, and migration in lung cancer by sponging miR-3918 to mediate FGFR1 expression.circNINL 通过海绵吸附 miR-3918 来调节 FGFR1 表达，促进肺癌细胞的有氧糖酵解、增殖、侵袭和迁移。
Eur J Med Res. 2024 Jan 20;29(1):67. doi: 10.1186/s40001-024-01636-7.
9
Investigating subtypes of lung adenocarcinoma by oxidative stress and immunotherapy related genes.通过氧化应激和免疫治疗相关基因研究肺腺癌的亚型。
Sci Rep. 2023 Nov 27;13(1):20930. doi: 10.1038/s41598-023-47659-8.
10
Recent advances on high-efficiency of microRNAs in different types of lung cancer: a comprehensive review.不同类型肺癌中微小RNA高效性的最新进展：综述
Cancer Cell Int. 2023 Nov 20;23(1):284. doi: 10.1186/s12935-023-03133-z.
LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
LY2874455 能够强效抑制 FGFR 守门员突变体并克服基于突变的耐药性。
Chem Commun (Camb). 2018 Oct 23;54(85):12089-12092. doi: 10.1039/c8cc07546h.
4
The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT.FGFR1 V561M 守门员突变通过 STAT3 激活和 EMT 驱动 AZD4547 耐药。
Mol Cancer Res. 2019 Feb;17(2):532-543. doi: 10.1158/1541-7786.MCR-18-0429. Epub 2018 Sep 26.
5
2'‑Hydroxyflavanone inhibits epithelial‑mesenchymal transition, and cell migration and invasion via suppression of the Wnt/β‑catenin signaling pathway in prostate cancer.2'‑羟基黄烷酮通过抑制 Wnt/β‑连环蛋白信号通路抑制前列腺癌细胞上皮‑间充质转化、迁移和侵袭。
Oncol Rep. 2018 Nov;40(5):2836-2843. doi: 10.3892/or.2018.6678. Epub 2018 Aug 31.
6
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
7
MicroRNA-590-5p functions as a tumor suppressor in breast cancer conferring inhibitory effects on cell migration, invasion, and epithelial-mesenchymal transition by downregulating the Wnt-β-catenin signaling pathway.微小 RNA-590-5p 在乳腺癌中作为一种肿瘤抑制因子发挥作用，通过下调 Wnt-β-连环蛋白信号通路来抑制细胞迁移、侵袭和上皮-间充质转化。
J Cell Physiol. 2019 Feb;234(2):1827-1841. doi: 10.1002/jcp.27056. Epub 2018 Sep 7.
8
Mn12Ac inhibits the migration, invasion and epithelial-mesenchymal transition of lung cancer cells by downregulating the Wnt/β-catenin and PI3K/AKT signaling pathways.Mn12Ac通过下调Wnt/β-连环蛋白和PI3K/AKT信号通路来抑制肺癌细胞的迁移、侵袭和上皮-间质转化。
Oncol Lett. 2018 Sep;16(3):3943-3948. doi: 10.3892/ol.2018.9136. Epub 2018 Jul 11.
9
TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells.TNFAIP3 对于 FGFR1 激活促进的癌前 DCIS.COM 人乳腺上皮细胞的增殖和致瘤作用是必需的。
Breast Cancer Res. 2018 Aug 15;20(1):97. doi: 10.1186/s13058-018-1024-9.
10
A phase Ib study of BGJ398, a pan-FGFR kinase inhibitor in combination with imatinib in patients with advanced gastrointestinal stromal tumor.BGJ398 联合伊马替尼治疗晚期胃肠间质瘤的 Ib 期研究：一种泛 FGFR 激酶抑制剂。
Invest New Drugs. 2019 Apr;37(2):282-290. doi: 10.1007/s10637-018-0648-z. Epub 2018 Aug 13.