Mueller D W, Bosserhoff A K
Institute of Pathology, Molecular Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg D-93053, Germany.
Br J Cancer. 2009 Aug 18;101(4):551-6. doi: 10.1038/sj.bjc.6605204. Epub 2009 Jul 28.
Analysis of microRNA (miRNA) biogenesis and function is an area of research that started only recently but has subsequently accelerated tremendously. This is because of the impressive impact of miRNA-mediated gene regulation and the obvious potential of those tiny RNA molecules in future diagnostic and therapeutic applications. In this review, recent progress to reveal the role of miRNAs in the tumourigenesis of malignant melanoma, as well as future prospects of melanoma-related miRNA research, will be addressed.
微小RNA(miRNA)生物合成与功能分析是一个起步较晚但发展迅猛的研究领域。这是因为miRNA介导的基因调控产生了令人瞩目的影响,且这些微小RNA分子在未来诊断和治疗应用中具有明显潜力。在本综述中,将探讨揭示miRNA在恶性黑色素瘤肿瘤发生中的作用的最新进展,以及黑色素瘤相关miRNA研究的未来前景。