Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Acta Paediatr. 2011 Nov;100(11):1454-60. doi: 10.1111/j.1651-2227.2011.02359.x. Epub 2011 Jun 16.
To evaluate health-related quality-of-life (HR-QoL) and the asthma control test (ACT) in children with problematic severe asthma and those with controlled asthma and to identify whether clinical characteristics show correlations with these measurements.
This multicentre cross-sectional study included 93 children in total, 54 with problematic severe asthma and 39 age-matched with controlled asthma. Subjects completed the Paediatric Asthma Quality-of-Life Questionnaire as well as a standardized health questionnaire and the ACT. Objective measurements of exhaled nitric oxide, specific sensitization, pulmonary function and bronchial hyper-responsiveness to methacholine were also taken.
HR-QoL was reduced in children with problematic severe asthma (5.4 vs. 6.7, p < 0.001), particularly for girls (5.1 vs. 5.6 for boys, p = 0.02), and their ACT scores were also lower (17 vs. 23, p < 0.001) compared with those of subjects with controlled asthma. A HR-QoL score <6.2 discriminated problematic severe asthma from controlled asthma with 85% sensitivity and 97% specificity, as did the ACT score <20 (79% sensitivity and 94% specificity). Objective measures and other clinical characteristics were weakly associated with HR-QoL or ACT score.
Subjective measurements of HR-QoL and asthma control are both equally useful in differentiating children with problematic severe asthma from those with controlled asthma.
评估患有严重问题性哮喘和控制良好哮喘的儿童的健康相关生活质量（HR-QoL）和哮喘控制测试（ACT），并确定临床特征是否与这些测量结果相关。
这是一项多中心的横断面研究，共纳入 93 名儿童，其中 54 名患有严重问题性哮喘，39 名年龄匹配的哮喘控制良好。受试者完成了儿童哮喘生活质量问卷以及标准化健康问卷和 ACT。还进行了呼出气一氧化氮、特异性致敏、肺功能和乙酰甲胆碱支气管高反应性的客观测量。
患有严重问题性哮喘的儿童的 HR-QoL 降低（5.4 与 6.7，p < 0.001），特别是女孩（5.1 与男孩的 5.6，p = 0.02），并且他们的 ACT 评分也较低（17 与 23，p < 0.001）与控制良好的哮喘患者相比。HR-QoL 评分 <6.2 可区分严重问题性哮喘与控制良好的哮喘，敏感性为 85%，特异性为 97%，ACT 评分 <20 也是如此（敏感性为 79%，特异性为 94%）。客观测量和其他临床特征与 HR-QoL 或 ACT 评分的相关性较弱。
HR-QoL 和哮喘控制的主观测量在区分患有严重问题性哮喘和控制良好哮喘的儿童方面同样有用。
