Scientific Institute of Public Health, 14 rue J. Wytsman, B-1050 Brussels, Belgium.
Chemosphere. 2011 Jun;84(3):279-88. doi: 10.1016/j.chemosphere.2011.04.048. Epub 2011 May 18.
A study was performed to assess exposure of the Belgian population to HBCD diastereoisomers. Measurements of HBCD were performed by UPLC-MS/MS, on 45 composite samples from 5 major food groups: dairy (products), meat (products), eggs, fish (products) and a group of "other" products. The medium bound estimated average daily intake (EDI) of ΣHBCD in the Belgian population was 0.99 ng kg(-1)bw d(-1). The diastereoisomer contribution to the mean EDI showed a predominance of γ-HBCD at 67%, followed by α-HBCD at 25% and 8% for β-HBCD. These results are consistent with the pattern found in the two food groups contributing the most to the EDI: meat (products) and the group of "other" products. Anyway, it has to be noted that diastereomeric distribution of HBCD can change due to bioisomerisation in biological material. Levels of HBCD diastereoisomers found in Belgian food samples of animal origin were low in comparison with those found in other EU countries and the resulting EDI was substantially below the proposed thresholds.
开展了一项研究，以评估比利时人口接触六溴环十二烷非对映异构体的情况。采用超高效液相色谱-串联质谱法（UPLC-MS/MS）对来自 5 大食品类别的 45 个复合样本进行了 HBCD 测量：奶制品（产品）、肉类（产品）、蛋类、鱼类（产品）和“其他”产品组。比利时人口中ΣHBCD 的中值估计平均每日摄入量（EDI）为 0.99 ng kg(-1)bw d(-1)。非对映异构体对平均 EDI 的贡献显示γ-HBCD 占 67%，其次是 α-HBCD 占 25%，β-HBCD 占 8%。这些结果与对 EDI 贡献最大的两类食品一致：肉类（产品）和“其他”产品组。无论如何，必须注意的是，HBCD 的非对映异构体分布可能会因生物材料中的生物异构化而发生变化。与其他欧盟国家相比，在比利时动物源性食品样本中发现的 HBCD 非对映异构体水平较低，由此产生的 EDI 大大低于建议的阈值。
