Department of Pharmacology, Institute of Post Graduate Medical Education and Research, 244 B, Acharya JC Bose Road, Kolkata, West Bengal 700020, India.
Phytomedicine. 2011 Sep 15;18(12):1056-69. doi: 10.1016/j.phymed.2011.03.004. Epub 2011 May 18.
Diseases caused by insect borne trypanosomatid parasites are significant, yet remain a neglected public health problem. Leishmania, a unicellular protozoan parasite is the causative organism of Leishmaniasis and is transmitted by female phlebotamine sandflies affecting millions of people worldwide. In the wake of resistance to pentavalent antimonial drugs, new therapeutic alternatives are desirable. The plant kingdom has in the past provided several affordable compounds and this review aims to provide an overview of the current status of available leishmanicidal plant derived compounds that are effective singly or in combination with conventional anti-leishmanial drugs, yet are non toxic to mammalian host cells. Furthermore, delineation of the contributory biochemical mechanisms involved in mediating their effect would help develop new chemotherapeutic approaches.
由昆虫传播的利什曼原虫寄生虫引起的疾病很严重，但仍然是一个被忽视的公共卫生问题。利什曼原虫是一种单细胞原生动物寄生虫，是利什曼病的病原体，由雌性嗜人锥蝽传播，影响着全球数百万人。在对五价锑药物产生耐药性之后，人们渴望寻找新的治疗方法。过去，植物界提供了几种负担得起的化合物，本综述旨在概述目前可用的具有杀利什曼原虫作用的植物衍生化合物的现状，这些化合物单独使用或与传统抗利什曼病药物联合使用既有效，又对哺乳动物宿主细胞无毒。此外，阐明介导其作用的相关生化机制有助于开发新的化疗方法。
