Cell biology. The TASCC of secretion.
作者信息
Zoncu Roberto, Sabatini David M
机构信息
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
出版信息
Science. 2011 May 20;332(6032):923-5. doi: 10.1126/science.1207552.
Abstract
摘要
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Four faces of cellular senescence.细胞衰老的四个方面。
J Cell Biol. 2011 Feb 21;192(4):547-56. doi: 10.1083/jcb.201009094. Epub 2011 Feb 14.
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Regulation mechanisms and signaling pathways of autophagy.自噬的调控机制与信号通路。
Annu Rev Genet. 2009;43:67-93. doi: 10.1146/annurev-genet-102808-114910.
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Senescence-messaging secretome: SMS-ing cellular stress.衰老信息分泌组：传递细胞应激信号
Nat Rev Cancer. 2009 Feb;9(2):81-94. doi: 10.1038/nrc2560. Epub 2009 Jan 9.
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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.衰老相关分泌表型揭示了致癌RAS和p53肿瘤抑制因子的细胞非自主功能。
PLoS Biol. 2008 Dec 2;6(12):2853-68. doi: 10.1371/journal.pbio.0060301.
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Living on a break: cellular senescence as a DNA-damage response.暂停状态下的生存：细胞衰老作为一种DNA损伤反应
Nat Rev Cancer. 2008 Jul;8(7):512-22. doi: 10.1038/nrc2440.
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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.由白细胞介素依赖性炎症网络介导的癌基因诱导的衰老
Cell. 2008 Jun 13;133(6):1019-31. doi: 10.1016/j.cell.2008.03.039.
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Chemokine signaling via the CXCR2 receptor reinforces senescence.通过CXCR2受体的趋化因子信号传导会增强细胞衰老。
Cell. 2008 Jun 13;133(6):1006-18. doi: 10.1016/j.cell.2008.03.038.
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Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.致癌性BRAF通过由分泌蛋白IGFBP7介导的途径诱导衰老和凋亡。
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Many roads lead to oncogene-induced senescence.通向癌基因诱导衰老的途径有很多。
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