Hardell L, Eriksson M, Athlin L, Hansson M, Rappe C
UMEA UNIV HOSP,DEPT ONCOL,S-90185 UMEA,SWEDEN. UMEA UNIV HOSP,DEPT SURG,S-90185 UMEA,SWEDEN. UMEA UNIV,INST ENVIRONM CHEM,S-90187 UMEA,SWEDEN.
Oncol Rep. 1995 Sep;2(5):749-53. doi: 10.3892/or.2.5.749.
Epidemiological studies have suggested an association between exposure to phenoxyacetic acids, chlorophenols or their contaminating dioxins (PCDDs) and dibenzofurans (PCDFs) and soft-tissue sarcoma and malignant lymphoma. In this study adipose tissue concentrations of PCDDs and PCDFs were measured in nine patients with sarcoma or malignant lymphoma who had been exposed to phenoxyacetic acids or chlorophenols, or who had other potential exposure to dioxins and dibenzofurans. For comparison concentrations of PCDDs and PCDFs in a group of twelve healthy persons without any known exposure to the above chemicals and living in the same geographical area are presented. Even if no consistent pattern of PCDDs and PCDFs concentrations in the patients was demonstrated, the finding of increased concentrations in all three cases with non-Hodgkin's lymphoma is of special interest. The exposure profiles in relation to measured concentrations of PCDDs and PCDFs are discussed for all patients.
流行病学研究表明，接触苯氧基乙酸、氯酚或其污染的二噁英（多氯二苯并对二噁英）和二苯并呋喃（多氯二苯并呋喃）与软组织肉瘤和恶性淋巴瘤之间存在关联。在本研究中，对9例曾接触苯氧基乙酸或氯酚、或有其他潜在二噁英和二苯并呋喃接触史的肉瘤或恶性淋巴瘤患者的脂肪组织中多氯二苯并对二噁英和多氯二苯并呋喃的浓度进行了测量。为作比较，还给出了一组12名居住在同一地理区域、无上述化学品接触史的健康人的多氯二苯并对二噁英和多氯二苯并呋喃浓度。即使未证明患者体内多氯二苯并对二噁英和多氯二苯并呋喃浓度有一致规律，但在所有3例非霍奇金淋巴瘤患者中发现浓度升高仍特别令人关注。文中讨论了所有患者与所测多氯二苯并对二噁英和多氯二苯并呋喃浓度相关的接触情况。
