p65/RelA-Ser529 磷酸化 NF-κB 亚基诱导癫痫持续状态后自噬性星形胶质细胞死亡（Clasmatodendrosis）。
p65/RelA-Ser529 NF-κB subunit phosphorylation induces autophagic astroglial death (Clasmatodendrosis) following status epilepticus.
机构信息
Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, 200-702, South Korea.
出版信息
Cell Mol Neurobiol. 2011 Oct;31(7):1071-8. doi: 10.1007/s10571-011-9706-1. Epub 2011 May 20.
Abstract
Clasmatodendrosis is an irreversible astroglial degenerative change, which includes extensive swelling and vacuolization of cell bodies and disintegrated and beaded processes. This study was designed to elucidate whether clasmatodendrosis may be one of the autophagy-related degeneration of astrocytes. In this study, clasmatodendritic astrocytes were observed only in the stratum radiatum in the CA1 region. Vacuoles in clasmatodendritic astrocytes showed LAMP-1 immunoreactivity. In addition, both LC3-II and Beclin-1 expression were detected in most of clasmatodendritic astrocytes as well as a few non-vacuolized astrocytes. Clasmatodendritic astrocytes also showed p65/RelA-Ser529 phosphorylation in the nuclei. The neutralization of TNF-α by sTNFp55R infusion reduced clasmatodendritic astrocytes with nuclear p65/RelA-Ser529 phosphorylation. Therefore, these findings suggest that clasmatodendrosis may be autophagic astroglial death in response to epileptic seizures through TNF-α-mediated p65/RelA-Ser529 phosphorylation.
摘要
格子层状变性是一种不可逆的星形胶质细胞退行性变化，包括细胞体的广泛肿胀和空泡化以及解体和串珠样的突起。本研究旨在阐明格子层状变性是否可能是星形胶质细胞自噬相关变性的一种。在本研究中，仅在 CA1 区的放射层观察到格子层状变性的星形胶质细胞。格子层状变性星形胶质细胞的空泡显示 LAMP-1 免疫反应性。此外，LC3-II 和 Beclin-1 的表达在大多数格子层状变性星形胶质细胞以及少数无空泡化的星形胶质细胞中均有检测到。格子层状变性星形胶质细胞的核内也出现了 p65/RelA-Ser529 磷酸化。通过输注 sTNFp55R 中和 TNF-α 可减少具有核内 p65/RelA-Ser529 磷酸化的格子层状变性星形胶质细胞。因此，这些发现表明，格子层状变性可能是对癫痫发作的自噬性星形胶质细胞死亡，通过 TNF-α 介导的 p65/RelA-Ser529 磷酸化。
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