Stein H J, Schweigert M, Dubecz A
Klinik für Allgemein-, Viszeral- und Thoraxchirurgie, Klinikum Nürnberg, Deutschland.
Chirurg. 2011 Jun;82(6):495-9. doi: 10.1007/s00104-010-2038-8.
Endoscopic methods are increasingly propagated as oncologically adequate and less invasive treatment modalities for early esophageal cancer compared to surgery. The superiority or equality of endoscopic treatment has, however, so far not been proven by controlled trials. Current guidelines and an analysis of recently published data support surgical resection and lymphadenectomy as the standard of care for early esophageal cancer. This is based on the following arguments: 1) a reliable complete tumor resection with clear margins in all directions (R0 resection) including removal of all precancerous and precursor lesions can currently only be achieved by surgical resection, 2) none of the currently available staging tools allows definitive exclusion of lymphatic spread. A potentially curative surgical lymphadenectomy should thus only be omitted in well-defined subgroups. 3) In experienced hands surgical resection and lymphadenectomy can be performed with low mortality and morbidity, 4) reproducible and reliable data on long-term recurrence-free survival and quality of life are currently only available for surgical series. Thus, endoscopic therapy for early esophageal cancer is an alternative to surgical resection with lymphadenectomy only in patients unfit for surgery and in strictly defined low-risk situations.
与手术相比,内镜治疗方法作为早期食管癌的肿瘤学上充分且侵入性较小的治疗方式越来越多地得到推广。然而,迄今为止,内镜治疗的优越性或等同性尚未通过对照试验得到证实。当前的指南以及对近期发表数据的分析支持手术切除和淋巴结清扫作为早期食管癌的标准治疗方法。这基于以下论据:1)目前只有通过手术切除才能实现可靠的完整肿瘤切除,各方向切缘清晰(R0切除),包括切除所有癌前病变和前驱病变;2)目前可用的分期工具均无法明确排除淋巴转移。因此,仅在明确界定的亚组中才可省略潜在治愈性的手术淋巴结清扫。3)在经验丰富的医生手中,手术切除和淋巴结清扫可以在低死亡率和低发病率的情况下进行;4)目前只有手术系列有关于长期无复发生存率和生活质量的可重复且可靠的数据。因此,早期食管癌的内镜治疗仅在不适合手术的患者以及严格界定的低风险情况下可作为手术切除加淋巴结清扫的替代方法。