UNAM-Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey.
Carbohydr Polym. 2014 Jan;99:808-16. doi: 10.1016/j.carbpol.2013.08.097. Epub 2013 Sep 7.
One-step synthesis of size-tunable silver nanoparticles (Ag-NP) incorporated into electrospun nanofibers was achieved. Initially, in situ reduction of silver salt (AgNO3) to Ag-NP was carried out in aqueous solution of polyvinyl alcohol (PVA). Here, PVA was used as reducing agent and stabilizing polymer as well as electrospinning polymeric matrix for the fabrication of PVA/Ag-NP nanofibers. Afterwards, hydroxypropyl-beta-cyclodextrin (HPβCD) was used as an additional reducing and stabilizing agent in order to control size and uniform dispersion of Ag-NP. The size of Ag-NP was ∼8 nm and some Ag-NP aggregates were observed for PVA/Ag-NP nanofibers, conversely, the size of Ag-NP decreased from ∼8 nm down to ∼2 nm within the fiber matrix without aggregation were attained for PVA/HPβCD nanofibers. The PVA/Ag-NP and PVA/HPβCD/Ag-NP nanofibers exhibited surface enhanced Raman scattering (SERS) effect. Moreover, antibacterial properties of PVA/Ag-NP and PVA/HPβCD/Ag-NP nanofibrous mats were tested against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria.
一步法合成了尺寸可调的银纳米粒子（Ag-NP）并将其掺入到静电纺丝纳米纤维中。首先，在聚乙烯醇（PVA）的水溶液中进行银盐（AgNO3）的原位还原以生成 Ag-NP。在这里，PVA 既可用作还原剂和稳定剂，也可用作制备 PVA/Ag-NP 纳米纤维的电纺聚合物基质。然后，羟丙基-β-环糊精（HPβCD）被用作额外的还原剂和稳定剂，以控制 Ag-NP 的尺寸和均匀分散性。Ag-NP 的尺寸约为 8nm，对于 PVA/Ag-NP 纳米纤维观察到一些 Ag-NP 聚集体，相反，对于 PVA/HPβCD 纳米纤维，Ag-NP 的尺寸从约 8nm 减小至约 2nm，且在纤维基质内没有发生聚集。PVA/Ag-NP 和 PVA/HPβCD/Ag-NP 纳米纤维表现出表面增强拉曼散射（SERS）效应。此外，还测试了 PVA/Ag-NP 和 PVA/HPβCD/Ag-NP 纳米纤维垫对革兰氏阴性（大肠杆菌）和革兰氏阳性（金黄色葡萄球菌）细菌的抗菌性能。
