Lal H, Forster M J
Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth 76107-2690.
Pharmacol Biochem Behav. 1990 Mar;35(3):747-50. doi: 10.1016/0091-3057(90)90319-d.
C57BL/6NNia and autoimmune NZB/BlNJ mice aged 12-14 months were tested for acquisition and retention of an active avoidance response following vehicle or flumazenil (40 mg/kg), a benzodiazepine antagonist. Acquisition and retention performance was improved in flumazenil-treated mice when compared with vehicle-treated mice, although the degree of improvement varied with the level of performance in vehicle-treated mice of each strain. The NZB/BlNJ mice, which generally performed more poorly than the C57BL/6NNia mice, showed the greater improvements following flumazenil. These results suggest that antagonism of benzodiazepine receptors leads to improved learning and/or memory performance in mice with spontaneous age-associated deficits.
对12至14月龄的C57BL/6NNia小鼠和自身免疫性NZB/BlNJ小鼠进行测试，观察其在给予赋形剂或氟马西尼（40毫克/千克，一种苯二氮䓬拮抗剂）后主动回避反应的获得和保持情况。与给予赋形剂的小鼠相比，氟马西尼处理的小鼠在获得和保持表现方面有所改善，尽管改善程度因每个品系给予赋形剂小鼠的表现水平而异。通常表现比C57BL/6NNia小鼠更差的NZB/BlNJ小鼠，在给予氟马西尼后改善更大。这些结果表明，苯二氮䓬受体拮抗作用可改善具有自发性年龄相关缺陷小鼠的学习和/或记忆表现。
