Forster M J, Popper M D, Retz K C, Lal H
Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth 76107-2690.
Behav Neural Biol. 1988 Mar;49(2):139-51. doi: 10.1016/s0163-1047(88)90462-1.
Acquisition and 48-h retention of a step-up active avoidance response were studied in separate age groups of C57BL/6NNia mice (aged 1.5, 3.5, 6, 12, or 26 months) and five strains of genetically autoimmune mice differing in life span. The C57BL/6NNia mice showed no change in ability to acquire the avoidance response between 1.5 and 3.5 months, but showed a steady decline in that ability thereafter. Mouse strains with early-onset autoimmune disorder (NZB/B1NJ, MRL/MpJ-lpr, and BXSB/MpJ) showed declines in acquisition capability between 1.5 and 3.5 months of age, whereas mouse strains with mild, late-onset autoimmune disorder (MRL/MpJ- + and NZBWF1/J) showed stable or improved acquisition during that period. Both the C57BL/6NNia and NZB/B1NJ mice showed age-dependent declines in 48-h retention performance by 12 months of age. These findings suggested that while 48-h retention performance deficits were most related to chronological age, avoidance acquisition deficits were related to development of autoimmunity.
在不同年龄组的C57BL/6NNia小鼠（1.5、3.5、6、12或26月龄）以及五种寿命不同的遗传性自身免疫小鼠品系中，研究了逐步增强的主动回避反应的习得及48小时保持情况。C57BL/6NNia小鼠在1.5至3.5月龄之间回避反应的习得能力没有变化，但此后该能力呈稳步下降。患有早发性自身免疫性疾病的小鼠品系（NZB/B1NJ、MRL/MpJ-lpr和BXSB/MpJ）在1.5至3.5月龄之间习得能力下降，而患有轻度、迟发性自身免疫性疾病的小鼠品系（MRL/MpJ- +和NZBWF1/J）在此期间习得能力保持稳定或有所提高。C57BL/6NNia和NZB/B1NJ小鼠在12月龄时均表现出48小时保持能力随年龄增长而下降。这些发现表明，虽然48小时保持能力缺陷与实际年龄最为相关，但回避反应习得缺陷与自身免疫的发展有关。
