Laboratory for Autoimmune Diseases, Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Tsurumi-ku, Yokohama City, Kanagawa, Japan.
FEBS Lett. 2011 Dec 1;585(23):3627-32. doi: 10.1016/j.febslet.2011.05.025. Epub 2011 May 17.
Autoimmune diseases are caused by multiple genes and environmental effects. In addition, genetic contributions and the number of associated genes differ among different diseases and ethnic populations. Genome-wide association studies (GWAS) on rheumatoid arthritis (RA) and multiple sclerosis (MS) show that these diseases share many genetic factors. Recently, in addition to the major histocompatibility complex (MHC) gene, other genetic loci have been found to be associated with the risk for autoimmune diseases. This review focuses on the search for genetic variants that influence the susceptibility to RA and MS as typical autoimmune diseases and discusses the future of GWAS.
自身免疫性疾病是由多种基因和环境因素共同作用引起的。此外，不同疾病和不同种族人群的遗传贡献和相关基因数量也存在差异。针对类风湿关节炎（RA）和多发性硬化症（MS）的全基因组关联研究（GWAS）表明，这些疾病存在许多共同的遗传因素。最近，除了主要组织相容性复合体（MHC）基因外，还发现了其他遗传位点与自身免疫性疾病的易感性有关。本文主要关注寻找影响 RA 和 MS 易感性的遗传变异，RA 和 MS 是两种典型的自身免疫性疾病，并讨论了 GWAS 的未来发展。
