Schumacher K A, Swobodnik W, Janowitz P, Zöller A, Friedrich J M
Radiologische Klinik, Universität Ulm.
Rofo. 1990 Apr;152(4):446-52. doi: 10.1055/s-2008-1046902.
The present study reports on morphological findings obtained from 15 patients who were submitted to percutaneous transhepatic contact dissolution of gallbladder concrements with methyl-tert.-butyl ether (MTBE) and--in case of slightly calcified gallstones (n = 10)--with ethylene diamine tetraacetic acid (EDTA). At a maximum intracystic catheter placement time of four days complete lysis was obtained in 12 patients. As could be depicted by CT, the solvents induced significant regional or disseminated chemical cholecystitis in the majority of all cases. However, these changes proved to be completely reversible within about five weeks. It is concluded that with certain types of gallstones contact dissolution can be an effective alternative therapeutic technique which, however, requires meticulous morphological controlling in view of the time-consuming treatment of calcified concrements.
本研究报告了15例接受经皮经肝用甲基叔丁基醚（MTBE）溶解胆囊结石治疗的患者的形态学研究结果，对于轻度钙化结石（n = 10）的患者，则使用乙二胺四乙酸（EDTA）进行治疗。在最长4天的囊内导管放置时间内，12例患者实现了结石完全溶解。CT显示，在大多数病例中，这些溶剂均引发了明显的局部或弥漫性化学性胆囊炎。然而，这些变化在约五周内被证明是完全可逆的。得出的结论是，对于某些类型的胆结石，接触溶解术可以成为一种有效的替代治疗技术，不过，鉴于钙化结石的治疗耗时较长，需要进行细致的形态学监测。
