Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Clin Chim Acta. 2011 Aug 17;412(17-18):1600-5. doi: 10.1016/j.cca.2011.05.013. Epub 2011 May 13.
Smoking has been reported to be associated with abnormal lipid metabolism. However, it remains uncertain whether adverse metabolic effects of smoking on dyslipidemia differ with gender. The objective of this study was to investigate the association between smoking and dyslipidemia in men and women.
We analyzed data from 2166 men and 3003 women aged ≥20 years assessed in the Third Korea National Health and Nutrition Examination Survey (2005). Dyslipidemia was defined according to the National Cholesterol Education Program-Adult Treatment Panel III.
The prevalence of dyslipidemia was higher in men than in women. The odds ratios (95% confidence interval) of dyslipidemia associated with current smoking were 1.35 (0.98-1.85) in men and 1.92 (1.19-3.10) in women (p for interaction with gender <0.001). After stratification by components of dyslipidemia, women smokers showed higher odds ratios of having high triglyceride and low high-density lipoprotein cholesterol than men smokers. The association between current heavy-smoking (≥20 pack-years) and dyslipidemia was stronger in women than in men.
The association between smoking and dyslipidemia was significantly different between men and women. Women smokers might be more susceptible to develop dyslipidemia than men smokers.
吸烟已被报道与脂质代谢异常有关。然而，吸烟对血脂异常的不良代谢影响是否因性别而异尚不确定。本研究旨在探讨吸烟与男性和女性血脂异常的关系。
我们分析了 2005 年第三次韩国国家健康和营养调查（KNHANES III）中 2166 名男性和 3003 名年龄≥20 岁的参与者的数据。血脂异常根据国家胆固醇教育计划-成人治疗小组 III 定义。
血脂异常在男性中的患病率高于女性。与当前吸烟相关的血脂异常的比值比（95%置信区间）在男性中为 1.35（0.98-1.85），在女性中为 1.92（1.19-3.10）（性别交互作用的 p<0.001）。根据血脂异常成分分层后，女性吸烟者的高甘油三酯和低高密度脂蛋白胆固醇的比值比高于男性吸烟者。与当前重度吸烟（≥20 包年）和血脂异常相关的关联在女性中比男性更强。
吸烟与血脂异常之间的关联在男性和女性之间存在显著差异。女性吸烟者比男性吸烟者更容易发生血脂异常。
