Behavioral Disease Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMC Public Health. 2020 May 13;20(1):673. doi: 10.1186/s12889-020-08809-z.
Smoking is the most preventable cause of most chronic diseases such as cardiovascular disease (CVD). Dyslipidemia is also an important risk factor for CVD. Yet, research has provided contradicting findings regarding the association between smoking and blood lipids. This paper examines the relationship between dyslipidemia and smoking based on the results of a cross-sectional sample of a Kurdish population in western Iran.
This population-based study was derived from the recruitment phase of Ravansar Non-Communicable Disease (RaNCD) cohort study. Logistic regression model adjusted by confounding variables was used to determine the relationship between smoking and blood lipid components. In addition, dose-response relationship between blood lipids and the number of smoked cigarettes was evaluated.
For the purpose of this study, 7586 participants were examined. The lifetime prevalence of smoking was 19.9%, and 11.8% were current smokers. The prevalence of dyslipidemia in current smokers (54.9%) was higher than former smokers (43.9%) and in turn former smokers higher than non-smokers (38.0%). Current smokers had greater risk of abnormal HDL cholesterol [OR (95% CI), 2.28(1.98 -2.62)] and triglyceride [OR (95% CI), 1.37(1.15 -1.67)] compared to non-smokers. There was no significant difference in total cholesterol and LDL cholesterol between the two groups. A dose-response relationship was found between the number of cigarettes smoked and HDL-C and TG but no relationship was observed in terms of total cholesterol and LDL-C.
As compared to non-smokers, current smokers and former smokers had abnormal HDL-C and triglyceride and abnormal total cholesterol and triglyceride, respectively. After quitting smoking, heavy smokers showed a more normal HDL-C and total cholesterol levels than the people who tended to smoke a lower number of cigarettes per day.
吸烟是大多数慢性病（如心血管疾病）的最可预防的原因。血脂异常也是心血管疾病的重要危险因素。然而，研究对于吸烟与血液脂质之间的关系提供了相互矛盾的发现。本文根据伊朗西部库尔德人群的横断面样本研究结果，检查了血脂异常与吸烟之间的关系。
这项基于人群的研究来源于拉万萨尔非传染性疾病（RaNCD）队列研究的招募阶段。使用调整混杂因素的逻辑回归模型来确定吸烟与血液脂质成分之间的关系。此外，还评估了血脂与吸烟数量之间的剂量-反应关系。
在这项研究中，共检查了 7586 名参与者。吸烟的终生患病率为 19.9%，目前吸烟者为 11.8%。目前吸烟者（54.9%）的血脂异常患病率高于前吸烟者（43.9%），而前吸烟者又高于不吸烟者（38.0%）。与不吸烟者相比，目前吸烟者发生异常高密度脂蛋白胆固醇[比值比（95%置信区间），2.28（1.98-2.62）]和甘油三酯[比值比（95%置信区间），1.37（1.15-1.67）]的风险更高。两组之间总胆固醇和 LDL 胆固醇无显著差异。在吸烟数量与 HDL-C 和 TG 之间存在剂量-反应关系，但在总胆固醇和 LDL-C 方面没有关系。
与不吸烟者相比，目前吸烟者和前吸烟者的 HDL-C 和甘油三酯异常，而总胆固醇和甘油三酯异常。戒烟后，重度吸烟者的 HDL-C 和总胆固醇水平比每天倾向于吸烟量较少的人更正常。
