大驳骨中的双吲哚生物碱和裂环环烯醚萜

Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G. Don.

机构信息

Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.

出版信息

Fitoterapia. 2011 Sep;82(6):798-804. doi: 10.1016/j.fitote.2011.04.013. Epub 2011 May 9.

DOI:10.1016/j.fitote.2011.04.013

PMID:21601617

Abstract

The ethanolic extract from stems of a Thai medicinal plant, Alstonia macrophylla Wall. ex G. Don (Apocynaceae) showed a significant inhibitory effect on acetylcholinesterase (AChE) determined by using Ellman assay. Four compounds i.e., a bisindole alkaloid, macralstonine (1), a new bisindole alkaloid, thungfaine (2), a secoiridoid glycoside, sweroside (3) and a new secoiridoid glycoside, naresuanoside (4) were isolated. Compound 4 showed moderate AChE and butyrylcholinesterase (BChE) inhibitory effects. Interestingly, compound 4 inhibited cell growth on human androgen-sensitive prostate cancer cell line (LNCaP) but no effect on viability of human foreskin fibroblast cells (HF).

摘要

泰国药用植物大驳骨（夹竹桃科）茎的乙醇提取物在埃勒曼试验中对乙酰胆碱酯酶（AChE）表现出显著的抑制作用。从该植物中共分离得到了 4 种化合物，即双吲哚生物碱马卡罗汀（1）、新的双吲哚生物碱图恩法因（2）、环烯醚萜苷物西罗莫司（3）和新的环烯醚萜苷物奈瑞索苷（4）。化合物 4 对乙酰胆碱酯酶和丁酰胆碱酯酶均表现出中等抑制作用。有趣的是，化合物 4 抑制人雄激素敏感前列腺癌细胞系（LNCaP）的细胞生长，但对人包皮成纤维细胞（HF）的活力没有影响。