从垂茉莉中分离得到的弯蒴藤型吲哚生物碱和山橙酰胺型吲哚生物碱及一个新的长春烷型二吲哚生物碱。
Angustilobine and andranginine type indole alkaloids and an uleine-secovallesamine bisindole alkaloid from Alstonia angustiloba.
机构信息
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
出版信息
Phytochemistry. 2011 Dec;72(17):2212-8. doi: 10.1016/j.phytochem.2011.08.001. Epub 2011 Aug 31.
A total of 20 alkaloids were isolated from the leaf and stem-bark extracts of Alstonia angustiloba, of which two are hitherto unknown. One is an alkaloid of the angustilobine type (angustilobine C), while the other is a bisindole alkaloid angustiphylline, derived from the union of uleine and secovallesamine moieties. The structures of these alkaloids were established using NMR and MS analysis. Angustilobine C showed moderate cytotoxicity towards KB cells.
从垂茉莉的叶和茎皮提取物中共分离得到 20 种生物碱，其中两种为新生物碱。一种为阿枯米灵型生物碱（阿枯米灵 C），另一种为双吲哚生物碱垂茉莉菲灵，由猪毛菜碱和 secovallesamine 部分结合而成。这些生物碱的结构通过 NMR 和 MS 分析确定。阿枯米灵 C 对 KB 细胞显示出中等的细胞毒性。
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