State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Biotechnol Adv. 2011 Nov-Dec;29(6):654-60. doi: 10.1016/j.biotechadv.2011.05.001. Epub 2011 May 13.
2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries and is mainly produced by chemical synthesis. An alternative method for the production of natural flavors and fragrances is the microbial transformation process, which is attracting increasing attention because it is an environmentally friendly process and the products are considered "natural". The production of 2-PE from L-phenylalanine by biotransformation is possible through the Ehrlich pathway and considerable progress has been made in the development of this process. The present report reviews recent advances in biotechnological production of 2-PE, with emphasis on the strategies used to increase production and the applications of in situ product removal techniques. Future research should focus on product scale-up and product recovery processes for the industrialization of microbial processes.
2-苯乙醇（2-PE）是一种具有玫瑰香味的重要芳香醇。它已广泛应用于化妆品、香水和食品工业，主要通过化学合成生产。微生物转化过程是生产天然香料和香精的替代方法，越来越受到关注，因为它是一种环保的过程，而且产品被认为是“天然的”。通过艾利希途径可以将 L-苯丙氨酸生物转化为 2-PE，在该过程的开发方面已经取得了相当大的进展。本报告综述了生物技术生产 2-PE 的最新进展，重点介绍了提高产量的策略以及原位产物去除技术的应用。未来的研究应集中在微生物过程的工业化生产的产品放大和产品回收过程上。
