Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India.
J Trop Pediatr. 2012 Apr;58(2):147-50. doi: 10.1093/tropej/fmr043. Epub 2011 May 20.
Fifty cases of severe malaria were studied for their oxidant and antioxidant status. Severe anemia (54%) was the most common presentation followed by hyperpyrexia, cerebral malaria and jaundice. Plasma malondialdehyde, protein carbonyl, nitrite, ascorbic acid and copper levels were significantly raised in cases as compared with controls (p < 0.001). Plasma ceruloplasmin, glutathione and superoxide dismutase levels were significantly decreased in children with severe malaria (p < 0.001). Plasma zinc was increased in cases but difference is not statistically significant. Significantly decreased level of nitrites and increased value of glutathione was found in patients with hemoglobinuria and jaundice, respectively. The significantly elevated malondialdehyde and protein carbonyl levels reflect the increased oxidative stress, whereas decreased levels of glutathione and superoxide dismutase point toward utilization of the antioxidants in severe malaria. Thus, changes in oxidants and antioxidants observed suggest the production of reactive oxygen species and their possible role in pathogenesis of severe malaria.
研究了 50 例严重疟疾患者的氧化应激和抗氧化状态。最常见的表现是严重贫血（54%），其次是高热、脑型疟疾和黄疸。与对照组相比，病例组血浆丙二醛、蛋白羰基、亚硝酸盐、抗坏血酸和铜水平显著升高（p<0.001）。严重疟疾患儿血浆铜蓝蛋白、谷胱甘肽和超氧化物歧化酶水平显著降低（p<0.001）。病例组血浆锌升高，但差异无统计学意义。血红蛋白尿和黄疸患者的亚硝酸盐水平显著降低，谷胱甘肽水平显著升高。丙二醛和蛋白羰基水平显著升高反映了氧化应激的增加，而谷胱甘肽和超氧化物歧化酶水平的降低表明在严重疟疾中抗氧化剂的消耗。因此，观察到的氧化剂和抗氧化剂的变化提示活性氧的产生及其在严重疟疾发病机制中的可能作用。
