疟疾对维生素 E 血水平的影响：系统评价和荟萃分析。
Effect of Malaria on Blood Levels of Vitamin E: A Systematic Review and Meta-Analysis.
机构信息
Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat 10400, Thailand.
Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila 1008, Philippines.
出版信息
Nutrients. 2023 Aug 5;15(15):3472. doi: 10.3390/nu15153472.
Vitamin E has an antioxidant property and is associated with protection against malaria. The current study used systematic review and meta-analysis approaches examining the variance in blood levels of vitamin E in malaria patients as compared with uninfected individuals. The protocol for the systematic review was registered with PROSPERO (CRD4202341481). Searches for pertinent studies were carried out on Embase, MEDLINE, Ovid, PubMed, Scopus, ProQuest, and Google Scholar. The combined effect estimate (Cohen's d) of the difference in vitamin E levels in malaria patients as compared with uninfected individuals was estimated using the random effects model. The searches yielded 2009 records, and 23 studies were included in the systematic review. The majority of the studies (80%) found that vitamin E levels were significantly lower in malaria patients than those who were not infected. Overall, the results revealed a significant reduction in blood levels of vitamin E in malaria patients when compared with uninfected individuals ( < 0.01, Cohen's d: -2.74, 95% CI: -3.72-(-1.76), I: 98.69%, 21 studies). There was a significant reduction in blood levels of vitamin E in patients suffering from severe malaria, in comparison with those experiencing less severe forms of the disease ( < 0.01, Cohen's d: -0.56, 95% CI: -0.85-(-0.26), I: 0%, 2 studies), but no variation in blood levels of vitamin E among patients suffering from either or malaria ( = 0.13, Cohen's d: -1.15, 95% CI: -2.62-0.33, I: 93.22%, 3 studies). In summary, the present study strongly suggests that vitamin E levels are significantly reduced in malaria patients, with a more pronounced decrease observed in cases of severe malaria. However, the type of malaria parasite, specifically or , did not appear to influence the levels of vitamin E. This study highlights the potential role of vitamin E in the pathogenesis of malaria and suggests that improved vitamin E status might be beneficial for improving disease outcomes.
维生素 E 具有抗氧化特性，与预防疟疾有关。本研究采用系统评价和荟萃分析方法，比较了疟疾患者与未感染者的血维生素 E 水平差异。该系统评价的方案已在 PROSPERO（CRD4202341481）上注册。在 Embase、MEDLINE、Ovid、PubMed、Scopus、ProQuest 和 Google Scholar 上进行了相关研究的检索。采用随机效应模型估计了疟疾患者与未感染者之间维生素 E 水平差异的合并效应估计值（Cohen's d）。检索共得到 2009 条记录，23 项研究纳入了系统评价。大多数研究（80%）发现，疟疾患者的维生素 E 水平明显低于未感染者。总体而言，与未感染者相比，疟疾患者的血维生素 E 水平显著降低（<0.01，Cohen's d：-2.74，95%CI：-3.72-（-1.76），I：98.69%，21 项研究）。与患有较轻疟疾的患者相比，患有严重疟疾的患者的血维生素 E 水平显著降低（<0.01，Cohen's d：-0.56，95%CI：-0.85-（-0.26），I：0%，2 项研究），但患有间日疟或恶性疟的患者之间的血维生素 E 水平没有差异（=0.13，Cohen's d：-1.15，95%CI：-2.62-0.33，I：93.22%，3 项研究）。总之，本研究强烈表明，疟疾患者的血维生素 E 水平明显降低，严重疟疾患者的降低更为明显。然而，疟原虫的类型，特别是间日疟或恶性疟，似乎并不影响维生素 E 的水平。本研究强调了维生素 E 在疟疾发病机制中的潜在作用，并表明改善维生素 E 状态可能有益于改善疾病结局。
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