疟疾与β-胡萝卜素水平之间的关联：一项系统评价与荟萃分析。

The Association between Malaria and β-Carotene Levels: A Systematic Review and Meta-Analysis.

作者信息

Kotepui Kwuntida Uthaisar, Mahittikorn Aongart, Wilairatana Polrat, Masangkay Frederick Ramirez, Kotepui Manas

机构信息

Medical Technology, School of Allied Health Sciences, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand.

Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

出版信息

Antioxidants (Basel). 2023 Aug 29;12(9):1687. doi: 10.3390/antiox12091687.

DOI:10.3390/antiox12091687

PMID:37759990

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10525879/

Abstract

BACKGROUND

β-Carotene, which is a prominent carotenoid with notable antioxidant properties, may play a role in countering the oxidative stresses induced by malaria. The association between β-carotene levels and malaria is not yet fully understood, prompting this systematic review and meta-analysis.

METHODS

A rigorous search of databases, including Nursing and Allied Health Premium, EMBASE, MEDLINE, Ovid, PubMed, Scopus, and Google Scholar, was undertaken to collate studies that focused on β-carotene levels in malaria patients. The selected studies underwent critical appraisal, followed by data extraction for a meta-analysis.

RESULTS

Of the 2498 records initially identified, 10 were deemed suitable for synthesis. A considerable number of these studies indicated a pronounced reduction in β-carotene levels among malaria patients in contrast with uninfected individuals. The meta-analysis, encompassing 421 malaria patients and 240 uninfected controls, revealed a significant correlation between reduced β-carotene levels and malaria ( < 0.01, Hedges's g: -1.26, 95% CI: -2.00-(-0.53), I: 93.86%, seven studies).

CONCLUSIONS

The conducted systematic review and meta-analysis corroborated the correlation between lower β-carotene levels and malaria. The intricate relationship between malaria and β-carotene merits deeper exploration. A comprehensive understanding of this association might pave the way for innovative therapeutic approaches leveraging the antioxidant attributes of β-carotene to combat malaria-induced oxidative stress.

摘要

背景

β-胡萝卜素是一种具有显著抗氧化特性的重要类胡萝卜素，可能在对抗疟疾诱导的氧化应激中发挥作用。β-胡萝卜素水平与疟疾之间的关联尚未完全明确，因此开展了这项系统评价和荟萃分析。

方法

对包括护理与联合健康高级数据库、EMBASE、MEDLINE、Ovid、PubMed、Scopus和谷歌学术在内的数据库进行了严格检索，以整理关注疟疾患者β-胡萝卜素水平的研究。对所选研究进行严格评估，随后进行数据提取以进行荟萃分析。

结果

在最初识别的2498条记录中，有10条被认为适合进行综合分析。这些研究中有相当数量表明，与未感染个体相比，疟疾患者的β-胡萝卜素水平显著降低。荟萃分析纳入了421名疟疾患者和240名未感染对照，结果显示β-胡萝卜素水平降低与疟疾之间存在显著相关性（<0.01，Hedges's g：-1.26，95%CI：-2.00-（-0.53），I²：93.86%，七项研究）。