大鼠肝脏含有一种有效的肌醇1,3,4,5-四磷酸3-磷酸酶内源性抑制剂。
Rat liver contains a potent endogenous inhibitor of inositol 1,3,4,5-tetrakisphosphate 3-phosphatase.
作者信息
Hodgson M E, Shears S B
机构信息
Inositol Lipid Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
出版信息
Biochem J. 1990 May 1;267(3):831-4. doi: 10.1042/bj2670831.
Abstract
When Ins(1,3,4,5)P4 was incubated with a rat liver 100,000 g supernatant, about 93% of the substrate was metabolized by a 5-phosphatase, and only 7% by a 3-phosphatase. Ion-exchange chromatography of the supernatant specifically increased its 3-phosphatase activity 72 +/- 3-fold. This activated enzyme was inhibited by a heat-stable factor present in both the soluble and particulate portions of the cell.
摘要
当肌醇（1,3,4,5）四磷酸与大鼠肝脏100,000g上清液一起温育时，约93%的底物被5-磷酸酶代谢，只有7%被3-磷酸酶代谢。上清液的离子交换色谱法使其3-磷酸酶活性特异性增加72±3倍。这种活化的酶受到细胞可溶性和颗粒部分中存在的一种热稳定因子的抑制。
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