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解脂耶氏酵母有两个功能性信号识别颗粒7S RNA基因。

The yeast Yarrowia lipolytica has two, functional, signal recognition particle 7S RNA genes.

作者信息

He F, Yaver D, Beckerich J M, Ogrydziak D, Gaillardin C

机构信息

Laboratoire de Genetique, Centre de Biotechnologie Agro-Industrielle, INAPGt, Thiverval Grignon, France.

出版信息

Curr Genet. 1990 Apr;17(4):289-92. doi: 10.1007/BF00314874.

DOI:10.1007/BF00314874
PMID:2160331
Abstract

Cells containing a deletion of either the SCR1 or SCR2 genes, which code for the 7SL RNA component of the signal recognition particle (SRP) homologue, were found to be viable. Two independent approaches demonstrated that cells containing deletions of both genes were inviable. Therefore, Yarrowia lipolytica contains two (and only two) functional 7SL RNA genes.

摘要

含有信号识别颗粒（SRP）同源物的7SL RNA成分编码基因SCR1或SCR2缺失的细胞被发现是有活力的。两种独立的方法证明，同时含有这两个基因缺失的细胞是无法存活的。因此，解脂耶氏酵母含有两个（且仅有两个）功能性7SL RNA基因。

相似文献

1
The yeast Yarrowia lipolytica has two, functional, signal recognition particle 7S RNA genes.解脂耶氏酵母有两个功能性信号识别颗粒7S RNA基因。
Curr Genet. 1990 Apr;17(4):289-92. doi: 10.1007/BF00314874.
2
Two genes encode 7SL RNAs in the yeast Yarrowia lipolytica.
Curr Genet. 1989 Dec;16(5-6):347-50. doi: 10.1007/BF00340713.
3
A mutant of 7SL RNA in Yarrowia lipolytica affecting the synthesis of a secreted protein.
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A mutation in the signal recognition particle 7S RNA of the yeast Yarrowia lipolytica preferentially affects synthesis of the alkaline extracellular protease: in vivo evidence for translational arrest.解脂耶氏酵母信号识别颗粒7S RNA中的突变优先影响碱性细胞外蛋白酶的合成：翻译停滞的体内证据
J Cell Biol. 1992 Feb;116(3):605-16. doi: 10.1083/jcb.116.3.605.
5
A mutation in the secretion pathway of the yeast Yarrowia lipolytica that displays synthetic lethality in combination with a mutation affecting the signal recognition particle.解脂耶氏酵母分泌途径中的一种突变，该突变与影响信号识别颗粒的突变相结合时表现出合成致死性。
Mol Gen Genet. 1999 Jun;261(4-5):601-9. doi: 10.1007/s004380050002.
6
Isolation and cloning of the Yarrowia lipolytica SEC65 gene, a component of the yeast signal recognition particle displaying homology with the human SRP19 gene.解脂耶氏酵母SEC65基因的分离与克隆，该基因是酵母信号识别颗粒的一个组分，与人类SRP19基因具有同源性。
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Identification of an essential Schizosaccharomyces pombe RNA homologous to the 7SL component of signal recognition particle.鉴定出一种与信号识别颗粒的7SL组分同源的粟酒裂殖酵母必需RNA。
Mol Cell Biol. 1988 Apr;8(4):1580-90. doi: 10.1128/mcb.8.4.1580-1590.1988.
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Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle.粟酒裂殖酵母和解脂耶氏酵母中与信号识别颗粒同源的小核糖核蛋白。
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4315-9. doi: 10.1073/pnas.85.12.4315.
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Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth.酿酒酵母和粟酒裂殖酵母含有信号识别颗粒54-kD亚基的同源物，在酿酒酵母中该同源物对生长至关重要。
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Yarrowia lipolytica SRP54 homolog and translocation of Kar2p.解脂耶氏酵母SRP54同源物与Kar2p的易位
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Sls1p stimulates Sec63p-mediated activation of Kar2p in a conformation-dependent manner in the yeast endoplasmic reticulum.在酵母内质网中，Sls1p以构象依赖的方式刺激Sec63p介导的Kar2p激活。

本文引用的文献

1
7SL RNA from Schizosaccharomyces pombe is encoded by a single copy essential gene.裂殖酵母的 7SL RNA 由一个单拷贝必需基因编码。
EMBO J. 1988 Jan;7(1):231-7. doi: 10.1002/j.1460-2075.1988.tb02804.x.
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Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.蛋白质在内质网上的转运III. 信号识别蛋白（SRP）导致依赖信号序列和位点特异性的链延伸停滞，这种停滞可被微粒体膜解除。
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Mutants of the yeast Yarrowia lipolytica defective in protein exit from the endoplasmic reticulum are also defective in peroxisome biogenesis.解脂耶氏酵母中在内质网蛋白输出方面存在缺陷的突变体在过氧化物酶体生物发生方面也存在缺陷。
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Molecular analysis of the gene family of the signal recognition particle (SRP) RNA of tomato.番茄信号识别颗粒（SRP）RNA基因家族的分子分析
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Translocation of proteins across the endoplasmic reticulum.蛋白质在内质网上的转运
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Molecular evolution of SRP cycle components: functional implications.信号识别颗粒（SRP）循环组件的分子进化：功能意义
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8
A mutation in the signal recognition particle 7S RNA of the yeast Yarrowia lipolytica preferentially affects synthesis of the alkaline extracellular protease: in vivo evidence for translational arrest.解脂耶氏酵母信号识别颗粒7S RNA中的突变优先影响碱性细胞外蛋白酶的合成：翻译停滞的体内证据
J Cell Biol. 1992 Feb;116(3):605-16. doi: 10.1083/jcb.116.3.605.
内质网蛋白质转运所需的膜相关蛋白质复合物的纯化。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7112-6. doi: 10.1073/pnas.77.12.7112.
4
One-step gene disruption in yeast.酵母中的一步基因破坏
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5
Structure and evolution of the 7SL RNA component of the signal recognition particle.信号识别颗粒的7SL RNA组分的结构与进化
EMBO J. 1984 Oct;3(10):2325-32. doi: 10.1002/j.1460-2075.1984.tb02134.x.
6
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum.信号识别颗粒包含一种对于蛋白质跨内质网转运至关重要的7S RNA。
Nature. 1982 Oct 21;299(5885):691-8. doi: 10.1038/299691a0.
7
Human 7SL RNA consists of a 140 nucleotide middle-repetitive sequence inserted in an alu sequence.人类7SL RNA由插入alu序列中的140个核苷酸的中间重复序列组成。
Cell. 1982 May;29(1):195-202. doi: 10.1016/0092-8674(82)90103-9.
8
A study of copulation, sporulation and meiotic segregation in Candida lipolytica.解脂耶氏酵母交配、孢子形成及减数分裂分离的研究
Arch Mikrobiol. 1973;92(1):69-83. doi: 10.1007/BF00409513.
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Rapid transfer of DNA from agarose gels to nylon membranes.DNA从琼脂糖凝胶快速转移至尼龙膜。
Nucleic Acids Res. 1985 Oct 25;13(20):7207-21. doi: 10.1093/nar/13.20.7207.
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Improvement of sporulation in the yeast Yarrowia lipolytica.解脂耶氏酵母中孢子形成的改善。
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