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蛋白质在内质网上的转运

Translocation of proteins across the endoplasmic reticulum.

作者信息

Simon S

机构信息

Laboratory of Cellular Biophysics, Rockefeller University, New York, New York 10021.

出版信息

Curr Opin Cell Biol. 1993 Aug;5(4):581-8. doi: 10.1016/0955-0674(93)90126-b.

DOI:10.1016/0955-0674(93)90126-b
PMID:8257599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7135464/
Abstract

The past year has seen significant advances in the field of protein translocation: the roles of the signal recognition particle and its receptor have been understood in greater detail; many membrane components responsible for translocation have been identified; and insight has been gained into how proteins cross membranes.

摘要

过去一年里，蛋白质转运领域取得了重大进展：信号识别颗粒及其受体的作用得到了更深入的了解；许多负责转运的膜成分已被确定；并且对蛋白质如何穿过膜也有了深入认识。

相似文献

1
Translocation of proteins across the endoplasmic reticulum.蛋白质在内质网上的转运
Curr Opin Cell Biol. 1993 Aug;5(4):581-8. doi: 10.1016/0955-0674(93)90126-b.
2
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane.信号序列识别与蛋白质靶向内质网膜
Annu Rev Cell Biol. 1994;10:87-119. doi: 10.1146/annurev.cb.10.110194.000511.
3
Protein translocation. Travelling by TRAM.
Nature. 1992 May 7;357(6373):22-3. doi: 10.1038/357022a0.
4
A protein of the endoplasmic reticulum involved early in polypeptide translocation.一种在内质网中早期参与多肽转运的蛋白质。
Nature. 1992 May 7;357(6373):47-52. doi: 10.1038/357047a0.
5
Components and mechanism of protein translocation across the ER membrane.
Antonie Van Leeuwenhoek. 1992 Feb;61(2):119-22. doi: 10.1007/BF00580618.
6
[Dynamics of proteins in the endoplasmic reticulum].
Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):1018-22.
7
TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum.转运体相关膜蛋白（TRAM）在新生分泌蛋白转运到内质网的过程中，调控其对细胞质溶胶的暴露。
Cell. 1998 Mar 6;92(5):621-31. doi: 10.1016/s0092-8674(00)81130-7.
8
[Flexibility of ER translocon and integration of membrane protein].[内质网转位子的灵活性与膜蛋白的整合]
Seikagaku. 2008 Oct;80(10):897-906.
9
The protein translocation machinery of the endoplasmic reticulum.内质网的蛋白质转运机制。
Philos Trans R Soc Lond B Biol Sci. 1982 Dec 24;300(1099):225-8. doi: 10.1098/rstb.1982.0168.
10
Protein translocation across and integration into membranes.蛋白质跨膜转运及整合入膜。
CRC Crit Rev Biochem. 1986;20(1):73-137. doi: 10.3109/10409238609115901.

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本文引用的文献

1
The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation.在转运早期，信号序列通过核糖体通道进入内质网膜处的非细胞质水环境。
Cell. 1993 Jun 18;73(6):1101-15. doi: 10.1016/0092-8674(93)90640-c.
2
Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation.哺乳动物内质网的腔内蛋白是完成蛋白质转运所必需的。
Cell. 1993 Jun 4;73(5):989-98. doi: 10.1016/0092-8674(93)90276-v.
3
Membrane topology and biogenesis of eukaryotic signal peptidase.真核信号肽酶的膜拓扑结构与生物发生
J Biol Chem. 1993 Mar 5;268(7):5201-8.
4
Yeast Wbp1p and Swp1p form a protein complex essential for oligosaccharyl transferase activity.酵母Wbp1p和Swp1p形成一种对寡糖基转移酶活性至关重要的蛋白质复合物。
EMBO J. 1993 Jan;12(1):279-84. doi: 10.1002/j.1460-2075.1993.tb05654.x.
5
The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids.转运体的SecA和SecY亚基是正在转运的前体蛋白的最近邻，使其免受磷脂的影响。
EMBO J. 1993 Jan;12(1):255-63. doi: 10.1002/j.1460-2075.1993.tb05651.x.
6
Translocation can drive the unfolding of a preprotein domain.易位可驱动前体蛋白结构域的去折叠。
EMBO J. 1993 Jan;12(1):243-53. doi: 10.1002/j.1460-2075.1993.tb05650.x.
7
Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70.从溶解的酵母膜中重建蛋白质易位揭示了BiP和胞质Hsc70在拓扑结构上的不同作用。
J Cell Biol. 1993 Jan;120(1):95-102. doi: 10.1083/jcb.120.1.95.
8
Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes.分泌前体蛋白插入微粒体膜需要特定长度的新生链。
J Cell Biol. 1993 Jun;121(6):1211-9. doi: 10.1083/jcb.121.6.1211.
9
Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog.信号识别颗粒54千道尔顿亚基被其大肠杆菌同源物进行功能替代。
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5229-33. doi: 10.1073/pnas.90.11.5229.
10
GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding.哺乳动物信号识别颗粒54-kD亚基的GTPase结构域是蛋白质转运所必需的，但不是信号序列结合所必需的。
J Cell Biol. 1993 Mar;120(5):1113-21. doi: 10.1083/jcb.120.5.1113.